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Chromogenic in situ hybridization (CISH) evaluation of human epidermal growth factor receptor 2 (HER 2) gene amplification in invasive duct carcinoma on tissue microarray TMA / Riham Farouk Gabr ; Supervised Amira Mohamed Raafat , Samir Ahmed Shawky , Rasha Ahmed Khairy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Riham Farouk Gabr , 2016Description: 105 P. : charts ; 25cmOther title:
  • تقييم اختبار التهجين الموضعى الملون فى البحث عن تضخيم جين الهير- تو فى حالات سرطان قنوات الثدى الغازى و ذلك باستخدام تقنية مصفوفة الأنسجة [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Human epidermal growth factor receptor 2 (HER2) is an important predictive marker in invasive duct carcinoma (IDC), for selecting anti-HER2 therapy candidates. Forty six IDC cases were tested for HER2 amplification by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) on a tissue microarray (TMA). A non cost manual method using pencil tips was used to construct two TMA blocks, where each case was represented by three cores. Comparing CISH and IHC results, it was found that there was 100% concordance between both tests in cases of IHC scores (+3,+1,0), and lesser concordance values in IHC equivocal +2 cases
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2016.Ri.C (Browse shelf(Opens below)) Not for loan 01010110071300000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.M.Sc.2016.Ri.C (Browse shelf(Opens below)) 71300.CD Not for loan 01020110071300000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology

Human epidermal growth factor receptor 2 (HER2) is an important predictive marker in invasive duct carcinoma (IDC), for selecting anti-HER2 therapy candidates. Forty six IDC cases were tested for HER2 amplification by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) on a tissue microarray (TMA). A non cost manual method using pencil tips was used to construct two TMA blocks, where each case was represented by three cores. Comparing CISH and IHC results, it was found that there was 100% concordance between both tests in cases of IHC scores (+3,+1,0), and lesser concordance values in IHC equivocal +2 cases

Issued also as CD

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