Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis

To assess and compare the role of contrast mammography versus dynamic contrast-enhanced MRI in detection of breast cancer recurrence after surgical treatment of primary breast cancer either by conservative surgery or by radical mastectomy. 30 female patients were included in this prospective study. This study was conducted in radiology department (women{u2019}s imaging unit), national cancer Institute (N.C.I) from August 2014 until October 2015. All cases underwent either breast conservative therapy or radical mastectomy at least 6 months before doing their CEDM and MRI. Recurrence mass lesion was suspected by clinical examination. Mammography was done followed by CEDM and MRI examination (with time interval between CEDM and MRI about two weeks). 30 female patients included in our study were pathologically proven to have recurrent breast cancer lesions. DCE-MRI could diagnose 28 cases from 30 with 2 false negative cases while CEDM could diagnose 26 cases from 30 with 4 false negative cases. In our study sensitivity of DCE-MRI (93.3%) was slightly higher than that of CEDM (86.7%) in detection of recurrent breast cancer lesions this slight difference in sensitivity was not of statistical significance (P value =0.014). Contrast enhanced digital mammography (CEDM) is feasible and has an important role in early detection of breast cancer recurrent lesion. The results of DCE-MRI are approaching that of contrast enhanced Mammography in diagnosis of breast cancer recurrent lesion, with MRI sensitivity slightly better than CEDM. CEDM is less expensive, easier and quicker examination compared to MRI

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