Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Radio-diagnosis

We performed a comparison between the role of F-18-FDG PET/CT and contrast enhanced MRI pelvis in the assessment of cancer cervix patients. Fifteen patients with pathologically proved cancer cervix underwent both F-18-FDG PET/CT and contrast enhanced MRI pelvis for initial staging, assessment of the therapeutic response post CRT and subsequent re-staging or for assessment of tumor residual/recurrence post-surgical excision. Both F-18-FDG PET/CT and contrast enhanced MRI pelvis were independently interpreted using visual (qualitative) analysis for both and quantitative analysis in the term of SUV max for F-18-FDG PET/CT. Using pathological data and / or combined clinical / radiological follow up as a reference standard, sensitivity, specificity, PPV, NPV, and over all accuracy were estimated for both techniques. Contrast enhanced MRI pelvis showed higher performance than PET/CT in assessment of local extensions of cervical cancer as PET/CT has limited spatial resolution. On contrast PET/CT was superior to pelvis MRI in monitoring the therapeutic response to CRT as well as determining lymph node status and possibility of distant metastatic disease presence. Meanwhile the both modalities showed equal performance in the assessment of local residual/recurrent lesions post-surgical excision. We found that MRI pelvis and F-18-FDG PET/CT play a complementary role in evaluation of cancer cervix patients. However PET/CT provides better assessment of therapeutic outcome

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