Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology

Node-negative breast cancer is a prevalent form of the disease worldwide, particularly in regions with rigorous screening and disease awareness efforts. Although there is a common biology between node negative and node positive breast tumors, it is still important to specifically address risk assessment and predictive factors in node negative breast cancer (harbeck and thomssen, 2011). Different breast cancer subtypes were newly recognized based on immunohistochemistry for ER, PR, HER2/neu and Ki-67, reflecting on patients{u2019} prognosis and management. We conducted this study to determine the prevalence of breast cancer subtypes in Egypt (national cancer institute, Cairo university) according to immunohistochemistry panel and to explore their association with node negative and other prognostic factors. A retrospective study carried out on one hundred and thirteen cases diagnosed as node negative invasive breast carcinoma at the pathology department, national cancer institute (NCI), Cairo university during the period from January 2007 to December 2010. The cases were classified into luminal A, luminal B, luminal-HER2/neu, HER2/neu-enriched and TNBC, using immunohistochemistry (ER, PR, HER2/neu and Ki-67). The obtained results were correlated with clinico-pathologic variables as well as 5-year DFS and 5-year OS. Cases were categorized into luminal A (31%), luminal B (35.4%), luminal HER2/neu (9.7%), HER2/neu-enriched (12.4%) and TNBC (11.5%). The majority of cases (85.8%) were low grade while the remaining cases (14.2%) were high grade. The difference was statistically significant (P value 0.001). Her2-negative cases showed slightly better 5-year DFS than Her2-positive cases with borderline statistical significant difference 89.3% versus 81.7%; respectively p=0.131

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