Value of FOXP3 expression in prediction of neoadjuvant chemotherapy effect in triple negative breast cancer / Hazem Abdelazim Sobhi Abo Ismael ; Supervised Badawia Bayoumi Ibrahim , Samar Abdelmonem Elsheikh , Iman Loay Hussein

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology

Response of breast carcinoma to neoadjuvant chemotherapy (NAC) varies regarding many factors including hormonal receptor status. Breast cancer is a heterogenous disease with different outcomes, hence a need arises for new markers predicting the outcome of NAC especially for the triple negative group when estrogen, progesterone receptors and her2/neu are negative. FOXP3 is a promising target with unclear role. The aim of this study was to examine the value of FOXP3 expression in locally advanced triple negative breast cancer tumoral cells as well as tumor infiltrating lymphocytes (TILs) and to elucidate its relation to the extent of NAC response. Forty five cases of immunohistochemically confirmed to be triple negative breast carcinoma were evaluated for NAC response in both tumour and lymph nodes status according to miller and payne's and Sataloff's systems. FOXP3 expression in tumor as well as TILs evaluated in the pretherapy biopsies was correlated with NAC response in breast tumor and lymph nodes as well as other clinicopathological factors. Breast tumour cells showed FOXP3 positive cytoplasmic expression in (42%) of cases. High FOXP3 expression percentage was detected in (47%) of cases. High infiltration by FOXP3+TILs was detected in (49%) of cases. Positive FOXP3 expression was associated with negative lymph node metastasis. High FOXP3 expression percentage and high infiltration by FOXP3+TILs were significantly associated with complete therapy response in axillary lymph nodes. High FOXP3 expression in tumour cells was associated with high infiltration by FOXP3+TILs

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