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Quantitative electromyography iIn prediction of carriers In duchenne muscle dystrophy / Manal Mohamed Gaber ; Supervised Hanan Hosny , Mona Abdelmeniem Nada , Ayatallah Farouk

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Manal Mohamed Gaber , 2016Description: 112 P. : facsimiles ; 25cmOther title:
  • التحليل الكمى للعضلات فى تشخيص حاملى مرض الدوشين [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurophysiology Summary: Background: Duchenne muscle dystrophy (DMD) is an x-linked severe progressive muscular dystrophy caused by deficiency of dystrophin. Objective: The aim of this study was to evaluate the role of quantitative EMG in the detection of myopathic carriers in DMD and assess the increase of micronucli that result from chromosomal malsegregation and breakage among carriers of DMD. Subjects and Methods: Subjects: 30 female carriers proved by +ve gentic study for DMD were included and matched to 30 controls. Methods: all subject were evaluated clinically, laboratory via CPK level, molecular genetics study and electrophysiology via routine EMG and NCS together with QEMG for both upper and lower limbs. Results: A statistically significant parameters of QEMG (p=0.004,0.002) were seen. Another statistically significant increase in CPK level and increase number of binucleated micronucleated lymphocytes were seen in the female carriers in comparison to the normal subjects. Conclusion: QEMG and genetic study have an important role in detection of female carriers of DMD
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.36.Ph.D.2016.Ma.Q (Browse shelf(Opens below)) Not for loan 01010110071939000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.36.Ph.D.2016.Ma.Q (Browse shelf(Opens below)) 71939.CD Not for loan 01020110071939000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurophysiology

Background: Duchenne muscle dystrophy (DMD) is an x-linked severe progressive muscular dystrophy caused by deficiency of dystrophin. Objective: The aim of this study was to evaluate the role of quantitative EMG in the detection of myopathic carriers in DMD and assess the increase of micronucli that result from chromosomal malsegregation and breakage among carriers of DMD. Subjects and Methods: Subjects: 30 female carriers proved by +ve gentic study for DMD were included and matched to 30 controls. Methods: all subject were evaluated clinically, laboratory via CPK level, molecular genetics study and electrophysiology via routine EMG and NCS together with QEMG for both upper and lower limbs. Results: A statistically significant parameters of QEMG (p=0.004,0.002) were seen. Another statistically significant increase in CPK level and increase number of binucleated micronucleated lymphocytes were seen in the female carriers in comparison to the normal subjects. Conclusion: QEMG and genetic study have an important role in detection of female carriers of DMD

Issued also as CD

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