Thesis (M.Sc.) - Cairo University -Faculty of Medicine - Department of Internal Medicine

Patients with chronic kidney disease (CKD) have markedly higher rates of severe vitamin D deficiency and reduced ability to convert 25- (OH)vitamin D into the active form, 1,25-dihydroxyvitamin D. In addition to the classical pathway for activation of 25-(OH)vitamin D to 1,25- (OH)₂ vitamin D, a peripheral autocrine pathway exists and results in calcitriol synthesis in a variety of peripheral extra-renal tissues. Focus on non-classical effects and possible less side effects of treatment with nutritional vitamin D, raises the expectation of possible benefits from treating chronic kidney disease (CKD) patients with "Native" vitamin D. Objective: In this study our aim is to evaluate the vitamin D status among our prevalent dialysis population. Methods: This cross sectional study includes seventy Patients randomly selected from our prevalent dialysis population and twenty healthy subjects with no chronic illness have been enrolled As a control cases. 25(OH)vitamin D estimated and patients who had 25(OH)vitamin D level {u2264}30 ng/ml were considered 25(OH)vitamin D deficient and patients who had 25(OH)vitamin D level >30 ng/ml are 25(OH)vitamin D sufficient. patients were subjected to Complete history taking and Full clinical examinations, Nutritional assessment, and Peripheral blood samples were analyzed for complete blood picture, serum albumin, serum calcium, serum phosphorus, serum uric acid, Alt, Pt, Ferritin, iPTH, and CRP. serum 25-hydroxyvitamin D was measured. 2 Results: We have noticed that (62.9%) of patients had 25(OH)vitamin D level {u2264} 30 ng/ml and (37.1%) had 25(OH)vitamin D level > 30 ng/ml. In the control group (65%) had 25(OH)vitamin D level {u2264} 30 ng/ml and (35%) had 25(OH)vitamin D level > 30 ng/ml. No significant association was found between 25-hydroxyvitamin D and age, sex, body mass index, parathyroid hormone, Hb%, ferritin, , comorbidity (cardiac, others), hospitalization periods and duration of dialysis

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