Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Pedodontics

Many studies have reported that Acute Lymphoid Leukemia (ALL) is the most common type of cancer in children. The annual incidence of ALL in the Egyptian population was found to be 4 in every 100,000 children. The increase of childhood cancer survivors has allowed to investigate the long-term effects of cancer treatment. Researches have linked chemotherapy to some dental abnormalities including teeth hypodontia, microdontia, enamel defects, root disturbances and altered dental age as well as developing of new carious lesions. Accordingly, the aim of this study was to investigate the long-term effects of chemotherapy on the development of permanent dentition in patients who were treated from ALL. This cross section study was performed on 94 ALL survivors ranging from 6-18 years old who attended Children Cancer Hospital 57357, Egypt. Patients were diagnosed as Low-risk or Standard-risk patients according to protocol XV for ALL patients (Pui et al., 2000). All patients have finished their programmed chemotherapy treatment before commencement of the study. In an attempt to correlate any dental abnormalities found in the study subjects to chemotherapy, a control group of age-matched 24 healthy individuals were enrolled from the orthodontic department, Cairo University, Egypt. Study groups were clinically examined for the presence or absence of missing teeth, microdontia, malformed teeth, enamel defects and supernumerary teeth

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