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Development and validation of analytical methods for the determination of some phosphodiesterase type-5 inhibitors / Ayoub Nagi Mohammed Mozayad ; Supervsied Ramzia Ismail Elbagary , Ehab Farouk Elkady

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ayoub Nagi Mohammed Mozayad , 2016Description: 201 P. ; 25cmOther title:
  • تطوير و التحقق من فعالية طرق تحليلية لتقدير بعض مثبطات الفوسفوداياستيراز نوع -5 [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: This thesis is concerned with the development of simple and accurate methods for the determination of some phosphodiesterase type-5 inhibitors in their pure and in pharmaceutical dosage forms. These drugs include avanafil, tadalafil and sildenafil. Three HPLC methods using spectrophotometric detector for the determination of avanafil, sildenafil and dapoxetine in ternary mixtures and the determination of sildenafil, dapoxetine and duloxetine or fluoxetine hydrochloride in ternary mixture and also the simultaneous determination of tadalafil, sildenafil, dapoxetine and duloxetine in quaternary mixture. Application of chemometric methods for the determination of five binary mixtures namely sildenafil/duloxetine, sildenafil/tadalafil, avanafil/dapoxetine, tadalafil/dapoxetine and sildenafil/ dapoxetine using CLS, PCR and PLS chemometric methods. Application of artificial Neural Network technique for the simultaneous determination of sildenafil and dapoxetine in binary mixture. The proposed methods were validated and statistically compared with reference methods where no significant difference was found
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2016.Ay.D (Browse shelf(Opens below)) Not for loan 01010110072121000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2016.Ay.D (Browse shelf(Opens below)) 72121.CD Not for loan 01020110072121000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

This thesis is concerned with the development of simple and accurate methods for the determination of some phosphodiesterase type-5 inhibitors in their pure and in pharmaceutical dosage forms. These drugs include avanafil, tadalafil and sildenafil. Three HPLC methods using spectrophotometric detector for the determination of avanafil, sildenafil and dapoxetine in ternary mixtures and the determination of sildenafil, dapoxetine and duloxetine or fluoxetine hydrochloride in ternary mixture and also the simultaneous determination of tadalafil, sildenafil, dapoxetine and duloxetine in quaternary mixture. Application of chemometric methods for the determination of five binary mixtures namely sildenafil/duloxetine, sildenafil/tadalafil, avanafil/dapoxetine, tadalafil/dapoxetine and sildenafil/ dapoxetine using CLS, PCR and PLS chemometric methods. Application of artificial Neural Network technique for the simultaneous determination of sildenafil and dapoxetine in binary mixture. The proposed methods were validated and statistically compared with reference methods where no significant difference was found

Issued also as CD

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