Design and synthesis of novel tetrahydrobeta-carbolines with a hydrophlilc side chain as potential phosphdiesterase 5 inhibitors and anticancer agents / Ahmed Kamal Mohammed Elhady ; Supervised Ashraf H. Abadi , Nazih Noureldin , Nermin Salah

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Ahmed Kamal Mohammed Elhady

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Material type: Text

TextLanguage: English Publication details: Cairo : Ahmed Kamal Mohammed Elhady , 2015Description: 110 Leaves : charts ; 30cmSubject(s):

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Dissertation note: Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: PDE5 enzyme is expressed in various parts of the human body, and thus PDE5 inhibitors has as PDE5 inhibitors for the treatment of MED and PAH, one of the most potent orreversble inhibitors of PDE5 enzyme currently present in the market it tadalafil; tadalafil is chemically classified as a tetrahydro-Ý- carboline-based PDE5 inhibitors. Recent studies showed that PDE5 and other PDEs are over-expressed in malignant tumors, thus inibiting these PDEs and the consequent rise of cGMP levels can lead to apoptosis and anticancer activities.

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Item type	Current library	Home library	Call number	Status	Barcode
Thesis	قاعة الثقاقات الاجنبية - الدور الثالث	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.34.M.Sc.2015.Ah.D (Browse shelf(Opens below))	Not for loan	01010110072199000

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Previous	Cai01.34.M.Sc.2015.Ad.I Improvement of fatigue strength of previously friction stir welded aluminum to steel sheets using appropriate post treatment process /	Cai01.34.M.Sc.2015.Ah.D Dynamic thermal investigation of ultra- thin silicon chips /	Cai01.34.M.Sc.2015.Ah.D Disturbance observe-based control of small-scale unmanned quadrotor /	Cai01.34.M.Sc.2015.Ah.D Design and synthesis of novel tetrahydrobeta-carbolines with a hydrophlilc side chain as potential phosphdiesterase 5 inhibitors and anticancer agents /	Cai01.34.M.Sc.2015.Ah.D Deterministic power prediction using enhanced 3D ray tracing for indoor coverage solutions /	Cai01.34.M.Sc.2015.Ah.E The effect of performance appraisal methods on employees' job performance in private sector companies in Egypt /	Cai01.34.M.Sc.2015.Ah.E Exhaustive execution of constraint handling rules through source-to-source transformation /	Next

Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

PDE5 enzyme is expressed in various parts of the human body, and thus PDE5 inhibitors has as PDE5 inhibitors for the treatment of MED and PAH, one of the most potent orreversble inhibitors of PDE5 enzyme currently present in the market it tadalafil; tadalafil is chemically classified as a tetrahydro-Ý- carboline-based PDE5 inhibitors. Recent studies showed that PDE5 and other PDEs are over-expressed in malignant tumors, thus inibiting these PDEs and the consequent rise of cGMP levels can lead to apoptosis and anticancer activities.

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