Development of salmonella typhimurium VNP20009 as a delivery vector for the novel neisserial anti-tumor protein laz / Manar Mahmoud Mansour Soliman ; Supervised Khaled AbouAisha , Shehab Amr Ismail , Mahmoud H. Abdelkader
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TextLanguage: English Publication details: Cairo : Manar Mahmoud Mansour Soliman , 2015Description: 78 Leaves : charts , facsimiles ; 30cmSubject(s): Dissertation note: Thesis (Ph.D.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Microbiology Summary: Salmonella typhimurium VNP20009 (hereafter referred to as VNP) is a non-pathogenic attenuated strain, which as a facultative anaerobe, preferentially accumulates in hypoxic regions of solid tumors. Here, VNP was exploited as a bacterial delivery vehicle of the anti-tumor protein laz (for lipidated azurin), which is produced by the meningitis-causing bacterium neisseria meningitidis. Unlike azurin, produced by pseudomonas aeruginosa, the neisserial azurin is a surface-exposed protein and possesses in its N-terminus a 39 amino acid epitope, termed H.8, which has been suggested to play a role in disrupting an entry barrier in brain tumor cells
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Thesis
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.Ph.D.2015.Ma.D (Browse shelf(Opens below)) | Not for loan | 01010110072251000 |
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Thesis (Ph.D.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Microbiology
Salmonella typhimurium VNP20009 (hereafter referred to as VNP) is a non-pathogenic attenuated strain, which as a facultative anaerobe, preferentially accumulates in hypoxic regions of solid tumors. Here, VNP was exploited as a bacterial delivery vehicle of the anti-tumor protein laz (for lipidated azurin), which is produced by the meningitis-causing bacterium neisseria meningitidis. Unlike azurin, produced by pseudomonas aeruginosa, the neisserial azurin is a surface-exposed protein and possesses in its N-terminus a 39 amino acid epitope, termed H.8, which has been suggested to play a role in disrupting an entry barrier in brain tumor cells
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