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MicroRNAs and liver fibrosis in hepatitis C patients / Asmaa M. Abdelwahab Mohamed ; Supervised Eman M. Gouda , Hanan A. Mohamed , Samy Zaky Elsayed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Asmaa Mohamed Abdelwahab Mohamed , 2016Description: 138 P. : charts , facsimiles ; 25cmOther title:
  • الأحماض النووية الريبوزية الصغيرة و التليف الكبدى فى مرضى الإلتهاب الكبدى الفيروسى- سى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition Summary: Egypt has the highest prevalence of hepatitis C virus (HCV) in the world. HCV chronic infection leads to progressive liver damage that ends finally with fibrosis. Predictive biomarkers for liver fibrosis progression are a must for treatment strategies development. Circulating microRNA levels have become a rapidly growing area of clinical research. Circulating miR-29 as a potential new hepatic stellate cell(HSC) activation marker and miR-155 as a positive regulator of inflammation were evaluated in the serum of chronic HCV patients, attended to AL-Azhar University Hospitals, relative to normal individuals and correlated these with clinical patient data. Our results reveal that, the level of miR-29b is decreased while miR-155 is increased in correlation to the fibrotic grade and fibrotic index in male and female chronic HCV patients. In conclusion, down-regulation of miR-29b and up-regulation of miR-155 are associated with the advance in fibrotic grade; making them a potential non-invasive biomarker for assessment of liver fibrosis in chronic HCV
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.04.M.Sc.2016.As.M (Browse shelf(Opens below)) Not for loan 01010110072520000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.04.M.Sc.2016.As.M (Browse shelf(Opens below)) 72520.CD Not for loan 01020110072520000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition

Egypt has the highest prevalence of hepatitis C virus (HCV) in the world. HCV chronic infection leads to progressive liver damage that ends finally with fibrosis. Predictive biomarkers for liver fibrosis progression are a must for treatment strategies development. Circulating microRNA levels have become a rapidly growing area of clinical research. Circulating miR-29 as a potential new hepatic stellate cell(HSC) activation marker and miR-155 as a positive regulator of inflammation were evaluated in the serum of chronic HCV patients, attended to AL-Azhar University Hospitals, relative to normal individuals and correlated these with clinical patient data. Our results reveal that, the level of miR-29b is decreased while miR-155 is increased in correlation to the fibrotic grade and fibrotic index in male and female chronic HCV patients. In conclusion, down-regulation of miR-29b and up-regulation of miR-155 are associated with the advance in fibrotic grade; making them a potential non-invasive biomarker for assessment of liver fibrosis in chronic HCV

Issued also as CD

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