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Chemical and biological assessment of cissus rotundifolia (Forssk.) vahl growing in Yemen / Akram Ali Mohamed Shalabi ; Supervised Essam A. Abdelsattar , Fatma Salem Elsakhawy , Mouchira Aly Choucry

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Akram Ali Mohamed Shalabi , 2017Description: 201 P. : charts , facsimiles ; 30cmOther title:
  • تقييم كيميائي و حيوى لنبات سيزوس روتنديفوليا (فورسك) فاهل الذي ينمو في اليمن [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy Summary: Cissus rotundifolia (Vitaceae) is an edible plant used traditionally in Yemen for the treatment of gastrointestinal troubles, in loss of appetite, skin diseases, burns and fever and used as antidiabetic and antimalarial. In the present work, the antidiabetic activity of the ethanolic extract prepared from the dried leaves and stems of C. rotundifolia, and its fractions; methylene chloride and n-butanol was evaluated in vitro by measuring Ü-glucosidase inhibitory activity and in vivo using STZ-induced diabetic rats. In vitro antioxidant activity was evaluated by using DPPH assay. All the tested extracts showed significant Ü-glucosidase inhibitory activity with methylene chloride fraction showed the highest activity with IC50 1.23±0.022 mg/ml compared to acarbose with IC50 0.789±0.009 mg/ml. In vivo study showed that all the tested extracts exhibited significant antidiabetic activity; with n-butanol fraction (300 mg/kg b.wt) showed the most potent activity as level of blood glucose decreased by 61.42 % compared to gliclazide (63.38 %) and insulin level was increased by 3.71 folds as compared to diabetic control group.
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.M.Sc.2017.Ak.C (Browse shelf(Opens below)) Not for loan 01010110072445000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.M.Sc.2017.Ak.C (Browse shelf(Opens below)) 72445.CD Not for loan 01020110072445000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

Cissus rotundifolia (Vitaceae) is an edible plant used traditionally in Yemen for the treatment of gastrointestinal troubles, in loss of appetite, skin diseases, burns and fever and used as antidiabetic and antimalarial. In the present work, the antidiabetic activity of the ethanolic extract prepared from the dried leaves and stems of C. rotundifolia, and its fractions; methylene chloride and n-butanol was evaluated in vitro by measuring Ü-glucosidase inhibitory activity and in vivo using STZ-induced diabetic rats. In vitro antioxidant activity was evaluated by using DPPH assay. All the tested extracts showed significant Ü-glucosidase inhibitory activity with methylene chloride fraction showed the highest activity with IC50 1.23±0.022 mg/ml compared to acarbose with IC50 0.789±0.009 mg/ml. In vivo study showed that all the tested extracts exhibited significant antidiabetic activity; with n-butanol fraction (300 mg/kg b.wt) showed the most potent activity as level of blood glucose decreased by 61.42 % compared to gliclazide (63.38 %) and insulin level was increased by 3.71 folds as compared to diabetic control group.

Issued also as CD

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