Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction: Intrauterine growth retardation (IUGR) is defined as those infants that failed to achieve their growth potential for age. In other words, fetal weight is below tenth percentile for age and sex. The IUGR infant is at risk to develop intrapartum fetal distress, meconium aspiration, polycythemia, impaired neuro logical development, necrotizing entero-colitis and intrauterine fetal death Methods:This study was a case-control study carried out at Neoantal Intensive Care unit (NICU), Cairo university hospitals. This study was conducted 50 neonates with IUGR including 22 males and 28 females another 30 healthy term neoantes (AGA) and all the infants enrolled in this studyenrolled to complete history taking, clilinical examination) weight, length and head circumference)and done complete complete blood count with differential count,CRP and antithrombinIII. Results: Polycythemia occurred in 36% of the IUGR infants, while occured in only 6.7% of AGA infants. Thrombocytopenia was found occured in 48% of IUGR infants and in 6.7% of AGA infants. Neutropenia was found to occur in 28% of IUGR infants and only in 6.7% of AGA infants. It was found that the level of anti-thrombin III decreased in 70% of IUGR infants and in 13.3% of AGA infants. Conclusion: IUGR infants are at increased risk polycythemia which increases the risk of respiratory distress and thrombosis, neutropenia which increases the risk of sepsis and thrombocytopenia which increases the risk of bleeding.antithrombinIII defeciency which increase thromboembolic episodes

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