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Assessment of a panel of diabetes genes expression in type 2 diabetic patients / Amira Nabil Abdelhamid Ahmed ; Supervised Sahar Abdelatty Sharaf , Nagwa Abdelaziz Kantoush , Rokaya Abdelaziz Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Amira Nabil Abdelhamid Ahmed , 2017Description: 200 P. : facsimiles ; 25cmOther title:
  • التقييم التعبيرى عن مجموعه من جينات السكرى فى مرضى البول السكرى من النوع الثانى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Up to 95% of all diabetes represents type 2 diabetes mellitus (T2DM). High morbidity and mortality rate is due to hyperglycemic direct and indirect effects on the vasculature resulting in multiple long-term microvascular complications. The emerging picture of genetics in T2DM involves risk susceptibility genes presumed to be implicated in T2DM pathogenesis and complications. KCNJ11 is KATP channel gene incorporated in cellular ion homeostasis and pancreatic beta cell insulin secretion. JAZF1 plays an important role in cell cycle regulation. WFS1 is implicated in pancreatic beta cell apoptosis via endoplasmic reticulum stress. PPARG is involved in insulin sensitivity. NOTCH2 is involved in normal pancreatic development and adult beta-cell survival of pancreas. EXOSC4 is related to cellular RNA processing and degradation. The present study aimed to investigate gene expression of (KCNJ11, JAZF1, WFS1, PPARG, NOTCH2 and EXOSC4) genes in peripheral blood of 100 subjects (30 non-complicated T2DM patients and 30 complicated T2DM patients versus 40 healthy controls) using quantitative Real Time PCR Array to identify genes that may be involved in T2DM pathogenesis and complications. Gene expression of KCNJ11, JAZF1, WFS1, and PPARG in complicated T2DM group was highly statistically significant lower than non-complicated T2DM group. Gene expression of NOTCH2 in complicated T2DM group was highly statistically significant higher than non-complicated T2DM group. Gene expression of EXOSC4 in complicated T2DM group showed no statistically significant difference compared to non-complicated T2DM group
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2017.Am.A (Browse shelf(Opens below)) Not for loan 01010110072636000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2017.Am.A (Browse shelf(Opens below)) 72636.CD Not for loan 01020110072636000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Up to 95% of all diabetes represents type 2 diabetes mellitus (T2DM). High morbidity and mortality rate is due to hyperglycemic direct and indirect effects on the vasculature resulting in multiple long-term microvascular complications. The emerging picture of genetics in T2DM involves risk susceptibility genes presumed to be implicated in T2DM pathogenesis and complications. KCNJ11 is KATP channel gene incorporated in cellular ion homeostasis and pancreatic beta cell insulin secretion. JAZF1 plays an important role in cell cycle regulation. WFS1 is implicated in pancreatic beta cell apoptosis via endoplasmic reticulum stress. PPARG is involved in insulin sensitivity. NOTCH2 is involved in normal pancreatic development and adult beta-cell survival of pancreas. EXOSC4 is related to cellular RNA processing and degradation. The present study aimed to investigate gene expression of (KCNJ11, JAZF1, WFS1, PPARG, NOTCH2 and EXOSC4) genes in peripheral blood of 100 subjects (30 non-complicated T2DM patients and 30 complicated T2DM patients versus 40 healthy controls) using quantitative Real Time PCR Array to identify genes that may be involved in T2DM pathogenesis and complications. Gene expression of KCNJ11, JAZF1, WFS1, and PPARG in complicated T2DM group was highly statistically significant lower than non-complicated T2DM group. Gene expression of NOTCH2 in complicated T2DM group was highly statistically significant higher than non-complicated T2DM group. Gene expression of EXOSC4 in complicated T2DM group showed no statistically significant difference compared to non-complicated T2DM group

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