Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology(Surgical)

Since trousseau{u2019}s time, the clinical association between cancer and venous thromboembolism has been observed. In fact it has been clearly established that cancer patients exhibit a higher risk of developing a thrombotic event when compared to non cancer patients, especially in the presence of well known risk factors for thrombosis, such as prolonged immobilization, surgery and chemo-radio-hormonal therapy. Haemostasis and malignancy share linking mechanisms in which it has been noticed that the hypercoagulable state acts as an important risk factor for thrombosis. It has also been noticed that a first episode of idiopathic VTE may represent the first manifestation of a yet undisclosed cancer, offering chances for an earlier diagnosis of the disease. The management of VTE in cancer patients include mechanical prophylaxis such as pneumatic calf compression added to the pharmacological prophylaxis. The use of an IVC filter should be considered in patients with a contraindication to anticoagulants. Proper diagnosis and evaluation is essential for early management. Medical treatment is the corner stone of cancer associated VTE, however, in some cases; surgical treatment may play a role

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