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Formulation and evaluation of certain modified release antidiabetic drug / Mohammed Raafat Mohammed Mannaa ; Supervised Ahmed Abdelbari Abdrahman , Mona Ibrahim Abdeltawab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammed Raafat Mohammed Mannaa , 2017Description: 181 P. Leaves : charts , photographs ; 25cmOther title:
  • صياغة وتقييم بعض المستحضرات الخافضة لمستوى السكر فى الدم والمعدلة الانطلاق [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Metformin HCl is widely used as anti-hyperglycemic agent for of treatment of type 2 non-insulin-dependent diabetes mellitus, as it has a short biological halflife; a long acting metformin HCl formulation is desirable to improve patient compliance. In this work, preparation of solid dispersions using solvent evaporation technique was applied for controlling release of metformin HCl, Thus, the work in this thesis was divided into the following chapters. Chapter (1): Compatibility study between biodegradable polymers and metformin HCl. This chapter includes a study of metformin HCl -polymer compatibility: Study of metformin HCl -polymer compatibility by DSC thermal analysis. Study of metformin HCl -polymer compatibility by FTIR Spectral analysis. Study of metformin HCl -polymer compatibility by x-ray Diffraction pattern. Results concluded that metformin HCl- polymers blends not affect the physical and chemical properties of drug . Chapter (2): Formulation and in-vitro evaluation of certain biodegradable metformin HClsolid dispersions. Preparation of solid dispersions using a solvent evaporation technique which involved preparation of a homogenous dispersion of metformin HCl in HPMC, EC, Eudragit RLPO, Eudragit RSPO and Compritol 888 ATO , the solid dispersions were characterized for their in-vitro release rate. An appropriate statistical model was made and a significantly controlled release rate was exhibited with the optimized formulation. In conclusion the statistical model enabled us to understand the effects of formulation variables on the solid dispersions
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Mo.F (Browse shelf(Opens below)) Not for loan 01010110072910000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Mo.F (Browse shelf(Opens below)) 72910.CD Not for loan 01020110072910000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Metformin HCl is widely used as anti-hyperglycemic agent for of treatment of type 2 non-insulin-dependent diabetes mellitus, as it has a short biological halflife; a long acting metformin HCl formulation is desirable to improve patient compliance. In this work, preparation of solid dispersions using solvent evaporation technique was applied for controlling release of metformin HCl, Thus, the work in this thesis was divided into the following chapters. Chapter (1): Compatibility study between biodegradable polymers and metformin HCl. This chapter includes a study of metformin HCl -polymer compatibility: Study of metformin HCl -polymer compatibility by DSC thermal analysis. Study of metformin HCl -polymer compatibility by FTIR Spectral analysis. Study of metformin HCl -polymer compatibility by x-ray Diffraction pattern. Results concluded that metformin HCl- polymers blends not affect the physical and chemical properties of drug . Chapter (2): Formulation and in-vitro evaluation of certain biodegradable metformin HClsolid dispersions. Preparation of solid dispersions using a solvent evaporation technique which involved preparation of a homogenous dispersion of metformin HCl in HPMC, EC, Eudragit RLPO, Eudragit RSPO and Compritol 888 ATO , the solid dispersions were characterized for their in-vitro release rate. An appropriate statistical model was made and a significantly controlled release rate was exhibited with the optimized formulation. In conclusion the statistical model enabled us to understand the effects of formulation variables on the solid dispersions

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