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Pharmaceutical studies on controlled release pre-oral delivery systems for poorly soluble antidiabetic drug / Ebtesam Wahman Hammam Elsayed ; Supervised Nadia M. Mursi , Laila H. Emara

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ebtesam Wahman Hammam Elsayed , 2017Description: 197 P. : facsimiles , photographs ; 25cmOther title:
  • دراسات صيدلانية على انظمة منضبطة الانطلاق تعطى عن طريق الفم لعقار قليل الذوبان مضاد لمرض السكرى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Controlled release (CR) dosage forms offer a lot of advantages such as; patient convenience, reduction of dosing frequency and improved safety. In addition, CR dosage forms are considered more economic as they enable reduction of the total amount of drug administered. Gliclazide is a second generation sulphonylurea, oral antidiabetic drug. In exhibits low solubility and high permeability (biopharmaceutical classification system, BCS, class {u2161}). The low water-solubility of gliclazide leads to a slow dissolution is considered as the rate limiting step for gliclazide absorption. It exhibits high inter-subject variation in its absorption. Oral administration of a single dose of gliclazide resylts in a varying maximum plasma concentration that ranges from 2.2 to 8 mg/L within 2 to 8 hours. This variability in the absorption was attributed to both the physicochemical properties of gliclazide as well as the formulation administered
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Eb.P (Browse shelf(Opens below)) Not for loan 01010110072911000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Eb.P (Browse shelf(Opens below)) 72911.CD Not for loan 01020110072911000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Controlled release (CR) dosage forms offer a lot of advantages such as; patient convenience, reduction of dosing frequency and improved safety. In addition, CR dosage forms are considered more economic as they enable reduction of the total amount of drug administered. Gliclazide is a second generation sulphonylurea, oral antidiabetic drug. In exhibits low solubility and high permeability (biopharmaceutical classification system, BCS, class {u2161}). The low water-solubility of gliclazide leads to a slow dissolution is considered as the rate limiting step for gliclazide absorption. It exhibits high inter-subject variation in its absorption. Oral administration of a single dose of gliclazide resylts in a varying maximum plasma concentration that ranges from 2.2 to 8 mg/L within 2 to 8 hours. This variability in the absorption was attributed to both the physicochemical properties of gliclazide as well as the formulation administered

Issued also as CD

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