The effect of melatonin on osseointegration of immediate loading implant supported mandibular overdentures = تاثير الميلاتونين علي الاندماج العظمي في التحميل الفوري على الغرسات / Doaa Amr Heshmat Rostom ; Supervised Alaa Aboul Ela , Mohammed Farouk Abdallah

Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Prosthodontics

In the recent years, immediate loading of implant is very demanding to shorten the time rehabilitation. Some authors claimed that Melatonin induce bone formation, increase bone density and bone implant contact, The aim of this study is to assess the effect of local melatonin administration on bone density around immediate loaded implant supported overdentureMaterial and method: Eight completely edentulous were selected .the Patient{u2019}s age ranged between 55 to 65 years old. The study was split mouth technique, each patient served as his own control, the study group (topical application of melatonin in the implant side), the control group (no melatonin in the other implant side of the same patients).Immediately after the implant placement, implant stability test was performed using the Osstell Monitor and Digora system was used for assessing the bone density changes. The Radiographic bone density measurements, implant stability assessment and implant survival were performed at time of loading then at three, six and twelve months after loading. The results: a high statistically significant difference in bone density and implant stability in the immediately loaded implants with local melatonin application (p=0.001).Conclusion;The local melatonin administration increase bone density and improve the osseointegration processes around immediate loaded implant supported overdentures

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