Synthesis of some azoles, azines and its fused derivatives with expected biological activity / Aly Mahmoud Mohamed Mohamed ; Supervised Abdou O. Abdelhamid , Nadia Abdelhamid , Wafaa M. Hossny

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

1-(5-methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethen-1-one was reacted with thiosemicarbazide, alkyl Carbodithioate, Benzaldehyde and Ethylformate gave thiosemicarbazone, alkyledene hydraziecarbodithioate,5-benzyledene-1,2,3triazole. 1,3,4-thiadiazole derivatives were abtaimed from reaction of alkyladene carbothioate with hydrazonoyl chlorides. Also, hydrazonyl halides were reacted with each of thiosemicarbazone and pyrazolinthioamid to give 5-arylazothiazoles derivative containing 1,2,3-triazole moiety. Howevere, the sodium salt of 3-(5-methyl-1-(p-tolyl)-1H-1,2,3- triazol-4-yl)-3-oxoprop-1-ene-1-oleate was used to synthezed some azolo[1,5-a] pyridenes, azolo[5,1-c] triazines, substituted pyridines. Azido (2-methyl-6-(5-methyl-1-(p-tolyl)-1H- 1,2,3-triazol-4-yl)-4-phenyl-pyridin-3-yl) methanone was reacted with aromatic amines and phenol to give substituted urea and arylcarbmate containing 1,2,3-triazole moiety. All the newly synthesized compounds were established by elemental analysis, spectral data and alternative synthies routes whenever possobile. Same of the srewly synthesized compounds was scrrem to wards macroorganism

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