Time trend analysis, clinicopathological study, and treatment outcome of T-cell lymphomas in different age groups / Ghada Mohamed Saad ; Supervised Hussein Mostafa Khaled , Raafat Mohamed Abdelfattah , Dalia Negm Eldin Mohamed

Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology(Medical)

Introduction: T-cell lymphoma represents a rare and heterogeneous group of non-hodgkin lymphomas with a very poor prognosis. Diagnosis can be challenging due to the need for extensive genetic and molecular markers for proper diagnosis and sub- classification. T-cell lymphomas are classified into two major groups: mature (PTCL) and immature. No standard first line treatment exists for PTCL and involving patients in clinical trials is the best option. Immature T cell lymphomas are best treated using childhood leukemia protocols. Aim of the work: To analyze and assess the clinicopathological characteristics of cases, treatment modalities and outcomes of T-cell lymphoma, as to date there have been no national or African studies focusing exclusively on this type of lymphoma. Patients and methods: Data of patients with PTCL and TLBL who presented to NCI and some private clinics during the period from year 2008-2014 were retrospectively reviewed. The total number of patients was 130 patients; 114 patients from NCI and 16 patients from private clinics. Of the cases that presented to NCI, only 64 patients received treatment while 12 patients did not receive any line of therapy, and we have not been able to retrieve the files of the remaining 38 patients. Results: Each year there was a 0.089% increase in the rate. This value was not statistically significant (p-value=0.600). The median age was 36.5 years with a male to female ratio of 2.4:1. The most common pathological site was nodal T cell lymphoma (74%), while the most common pathological subtype of PTCL was PTCL-NOS 17/74, 23%

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