Comparison of the effects of Albumin 5% versus Ringer's lactate on blood loss and coagulation after vascular surgery using thromboelastograph / Osama Ismail Fathy Zaid ; Supervised Nadia Gamil Elsharkawi , Nashwa Nabil Talaat , Ahmed Farag Mohamed

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia

Perioperative hemorrhage depends not only on surgical technique but also on coagulation competence of blood. Perioperative coagulation competence if of interest because administration of blood seems to be an independent predictor of complications including death. Monitoring perioperative coagulation relies on clinical estimates besides on classic plasma coagulation tests. However, plasma coagulation tests were designed to test for lack of coagulation factors and not for predicting risk of bleeding or for guiding hemostatic therapy. In contrast, viscoelastic evaluation of whole blood enables for rapid diagnosis of the cause of bleeding and may be displayed in real time within the operating theater . Thus , the use of perioperative coagulation monitoring by, for example , thromboelastography (TEG) for targeted treatment of coagulopathy is recommended by the European Society of Anaesthesiology (ESA). To address perioperative hemorrhage , coagulation competence, and patient outcome, a systematic review was undertaken including a meta-analysis for randomized controlled trials (RCTs) for the use of perioperative infusio

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