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Effect of narrow band UVB on the expression of Janus kinase in vitiligo and psoriasis / Sally Mamdouh Harmal AboElyamin ; Supervised Hanan Rabea Nada , Laila Ahmed Rashed , Dina Ahmed Elsharkawy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sally Mamdouh Harmal AboElyamin , 2016Description: 199 P. : facsimiles ; 25cmOther title:
  • تأثير الاشعة الفوق بنفسجية ضيقة النطاق على التعبير عن الجاك فى البهاق و الصدفية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology Summary: Back ground: Janus kinases (JAKs) are non-receptor protein tyrosine kinases and are expressed in many tissues and they function as signal transducers downstream of more than 50 cytokine and peptide hormone receptor complexes. Once the JAKs are activated, a cascade of further signaling events is triggered, involving phosphorylation of selected receptor chain tyrosines, binding of the so-called signal transducer and activator of transcription (STAT) proteins and phosphorylation of these STATs. Due to their ability to selectively modulate immune function, targeted JAK inhibitors are promising candidates for treatment of some skin diseases such as psoriasis and atopic dermatitis. Aim: The aim of this study was to assess the level of JAK1 in both vitiligo and psoriasis patients before and after treatment with NB-UVB. Method:Ten patients with psoriasis, 10 patients with vitiligo and 10 controls were enrolled into this study. JAK1 level before and after treatment with NB-UVB 311nm (12 sessions) was measured using western blot assay. Results:The level of JAK1 was significantly higher in vitiligo and psoriasis patients than controls. There was a decline in the level of JAK1after treatment, which was statistically significant. VASI and PASI scores of patients decreased after treatment with NB-UVB. In psoriatic patients,the JAK1 level positively correlate with the female gender, disease duration and PASI change
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.M.Sc.2016.Sa.E (Browse shelf(Opens below)) Not for loan 01010110073377000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.10.M.Sc.2016.Sa.E (Browse shelf(Opens below)) 73377.CD Not for loan 01020110073377000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Back ground: Janus kinases (JAKs) are non-receptor protein tyrosine kinases and are expressed in many tissues and they function as signal transducers downstream of more than 50 cytokine and peptide hormone receptor complexes. Once the JAKs are activated, a cascade of further signaling events is triggered, involving phosphorylation of selected receptor chain tyrosines, binding of the so-called signal transducer and activator of transcription (STAT) proteins and phosphorylation of these STATs. Due to their ability to selectively modulate immune function, targeted JAK inhibitors are promising candidates for treatment of some skin diseases such as psoriasis and atopic dermatitis. Aim: The aim of this study was to assess the level of JAK1 in both vitiligo and psoriasis patients before and after treatment with NB-UVB. Method:Ten patients with psoriasis, 10 patients with vitiligo and 10 controls were enrolled into this study. JAK1 level before and after treatment with NB-UVB 311nm (12 sessions) was measured using western blot assay. Results:The level of JAK1 was significantly higher in vitiligo and psoriasis patients than controls. There was a decline in the level of JAK1after treatment, which was statistically significant. VASI and PASI scores of patients decreased after treatment with NB-UVB. In psoriatic patients,the JAK1 level positively correlate with the female gender, disease duration and PASI change

Issued also as CD

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