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Assessment of the role of PPAR-Þ2 Pro12Ala polymorphism and D2 Thr92Ala polymorphism in type 2 diabetic patients / Ghada Mohamed Ahmed Abdelwahab ; Supervised Mohammed Shehata , Mona Fathy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ghada Mohamed Ahmed Abdelwahab , 2017Description: 111 P. : charta ; 25cmOther title:
  • فى مرضى النوع الثانى من داء السكرى D2 Thr92Ala و تعدد الأشكال الجينية ل PPAR-Þ2 Pro12Ala تقييم دور تعدد الأشكال الجينية ل [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Background: Peroxisome proliferator-activated receptor gamma 2 (PPAR-Þ2) is a transcription factor with a key role in adipocyte differentiation, lipid storage and glucose homeostasis. The Ala allele of the common Pro12Ala polymorphism in the isoform PPAR-Þ2 is at the center of many controversies because in some populations, it has been observed to be associated with T2DM or obesity but, not in others. Type 2 deiodinase (D2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the association of Pro12Ala polymorphism in the PPAR-Þ2 gene and Thr92Ala polymorphism in the D2 gene and type 2 diabetes mellitus. Subject and methods: This case-control study included 80 T2DM patients and 82 controls all unrelated. Genotyping of PPAR-Þ2 (Pro12Ala) and genotyping of D2 (Thr92Ala) polymorphisms were examined by using the restriction fragment length polymorphism -polymerase chain reaction (PCR-RFLP). Results: The frequency of the mutant homozygous of PPARG gene was 7.5% among T2DM and 6.1% among controls, while the frequency of the mutant homozygous of D2 gene was 15% among T2DM and 9.8% among controls. The genotype analysis of PPARG gene polymorphism, and D2 gene polymorphism revealed no statistically significant difference between the two studied groups, for PPARG (P=0.937), and for D2 (P=0.572). Conclusion: PPARG Pro12Ala polymorphism, D2 Thr92Ala polymorphism may not be associated with T2DM
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2017.Gh.A (Browse shelf(Opens below)) Not for loan 01010110073390000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2017.Gh.A (Browse shelf(Opens below)) 73390.CD Not for loan 01020110073390000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Background: Peroxisome proliferator-activated receptor gamma 2 (PPAR-Þ2) is a transcription factor with a key role in adipocyte differentiation, lipid storage and glucose homeostasis. The Ala allele of the common Pro12Ala polymorphism in the isoform PPAR-Þ2 is at the center of many controversies because in some populations, it has been observed to be associated with T2DM or obesity but, not in others. Type 2 deiodinase (D2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the association of Pro12Ala polymorphism in the PPAR-Þ2 gene and Thr92Ala polymorphism in the D2 gene and type 2 diabetes mellitus. Subject and methods: This case-control study included 80 T2DM patients and 82 controls all unrelated. Genotyping of PPAR-Þ2 (Pro12Ala) and genotyping of D2 (Thr92Ala) polymorphisms were examined by using the restriction fragment length polymorphism -polymerase chain reaction (PCR-RFLP). Results: The frequency of the mutant homozygous of PPARG gene was 7.5% among T2DM and 6.1% among controls, while the frequency of the mutant homozygous of D2 gene was 15% among T2DM and 9.8% among controls. The genotype analysis of PPARG gene polymorphism, and D2 gene polymorphism revealed no statistically significant difference between the two studied groups, for PPARG (P=0.937), and for D2 (P=0.572). Conclusion: PPARG Pro12Ala polymorphism, D2 Thr92Ala polymorphism may not be associated with T2DM

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