Impact of EBV infection in female breast cancer in the Nile Delta of Egypt / Hisham Abdelrahman Hassan Abdelrahman ; Supervised Mervat Sayed Mohamed , Hosam Zaghloul , Wafaa M. Hosny

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Hisham Abdelrahman Hassan Abdelrahman

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TextLanguage: English Publication details: Cairo : Hisham Abdelrahman Hassan Abdelrahman , 2016Description: 170 P. : charts , facsimiles ; 25cmOther title:

تأثير العدوى بفيروس ابشتين بار على سرطان الثدي عند النساء فى دلتا النيل بمصر [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: Objective: The role of EBV in breast cancer pathogenesis is still conflicting, this role was tested in Nile Delta by detecting the percentage of EBV prevalence and viral load in the female breast cancer samples. Methods: This study involved 60 breast carcinoma female patient samples. All samples were subjected to; First: histopathological markers , detection for tumor grade, tumor type (ductal or lobular), nodal status and tumor receptors (ER, PR, and Her2) using immunohistochemistry. Second: EBV DNA extraction, purification,and quantitation by real-time PCR. Statistical Package for the Social Sciences (SPSS) 17 program was used for performing results statistics. Results: Results were plotted in two tables, one for EBV detection and other for EBV viral load, and compared with the following clinicopathological markers: age, tumor size, tumor grade, tumor stage, tumor type (ductal or lobular), tumor nodal status and tumor receptors (ER, PR, and Her2). It was found that the prevalence ratio of EBV in breast cancer specimens was varied for each clinicopathological marker from 12.5% to 20.4% in all tested samples. A significant association was found in EBV prevalence with lymph node positive samples (P= 0.048) and a significant positive correlation of EBV viral load with old aged patients was found too (P = 0.035)

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.02.M.Sc.2016.Hi.I (Browse shelf(Opens below))		Not for loan		01010110073317000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.02.M.Sc.2016.Hi.I (Browse shelf(Opens below))	73317.CD	Not for loan		01020110073317000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry

Objective: The role of EBV in breast cancer pathogenesis is still conflicting, this role was tested in Nile Delta by detecting the percentage of EBV prevalence and viral load in the female breast cancer samples. Methods: This study involved 60 breast carcinoma female patient samples. All samples were subjected to; First: histopathological markers , detection for tumor grade, tumor type (ductal or lobular), nodal status and tumor receptors (ER, PR, and Her2) using immunohistochemistry. Second: EBV DNA extraction, purification,and quantitation by real-time PCR. Statistical Package for the Social Sciences (SPSS) 17 program was used for performing results statistics. Results: Results were plotted in two tables, one for EBV detection and other for EBV viral load, and compared with the following clinicopathological markers: age, tumor size, tumor grade, tumor stage, tumor type (ductal or lobular), tumor nodal status and tumor receptors (ER, PR, and Her2). It was found that the prevalence ratio of EBV in breast cancer specimens was varied for each clinicopathological marker from 12.5% to 20.4% in all tested samples. A significant association was found in EBV prevalence with lymph node positive samples (P= 0.048) and a significant positive correlation of EBV viral load with old aged patients was found too (P = 0.035)

Issued also as CD

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