Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Surgical)

10% of malignant lymphoma and 5% of gastric cancer. The most common type is diffuse large B cell lymphoma.The primary role of surgery or chemotherapy remains the mainstay is an issue of debate. However, there is, as yet, no randomized control trial to define the primary treatment of PGL, either surgery or chemotherapy or combined modality. Aim of the work: to highlight the clinical presentation and diagnostic work up of patients with primary gastric lymphoma and to review the different modalities of treatment and highlight the surgical treatment of early gastric lymphoma and complicated cases. Patient and methods: This retrospective study included patients with primary gastric lymphoma attended the National Cancer Institute between January 2008 and December 2012. Data was collected from the patients{u2019} medical records with minimum follow up period of 6 months from the date of surgery and histopathological features was obtained from the pathology department. Results: Primary gastric lymphoma is rare however; the incidence of this malignancy is increasing. Chronic gastritis secondary to H pylori infection has been considered a major predisposing factor for MALT lymphoma.Advances in imaging techniques including MRI and EUS have helped evaluation of tumor extension and invasion. The clinical course and prognosis of this disease is dependent on histopathological sub-type and stage at the time of diagnosis. Controversy remains regarding the best treatment for early stages of this disease. Chemotherapy possesses the advantage of preserving gastric anatomy. Radiotherapy alone has been tried and showed good results Stage IIIE, IVE disease treatment is solely by chemotherapy and surgical resection has been a remote consideration

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