Role of stem cell in delaying induced apoptosis and function loss of retinal photoreceptor cell in rabbits by argon laser as a model of retinitis pigmentosa / Ahmed Mostafa Abdelhalem Ahmed Ata ; Supervised Mohamed Ahmed Badawy , Hager Emam Amer , Layla Ahmed Rashed

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Ahmed Mostafa Abdelhalem Ahmed Ata

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TextLanguage: English Publication details: Cairo : Ahmed Mostafa Abdelhalem Ahmed Ata , 2017Description: 162 P. : charts , photographs ; 25cmOther title:

دور الخلايا الجذعية فى تأخير الموت المبرمج للخلايا و فقد وظيفة خلايا مستقبلات الضوء المستحث بالأرجون ليزر فى الأرانب كنموذج لمرض الإلتهاب الشبكى الصبغى [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: Retinitis pigmentosa (RP) is a serious genetically eye disease which leads to blindness .The purpose of this study is to regenerate the damaged photoreceptor cells as a result of argon laser as a model of RP in rabbits' retina by using MSCs from rabbits' bone marrow. This study used MSCs in two doses (3 million and 6 million) to be injected intravitreal to regenerate the damaged cells. Determination of the level of (GSH, NO, MDA, CP, AGE and MMP-2) in blood and retina. Ophthalmological and histological examinations were performed on all rabbits. A significant increase of serum NO, plasma MDA and serum CP and decrease of blood GSH in argon laser group as compared to control group. While in (MSCs) groups NO, MDA and CP decreased and GSH increased. Outer and inner segments of photoreceptor cells began to reconstruct in histological examination in (MSCs) groups after complete detachment in argon laser group. 6 milion dose gave better results than 3 million. In conclusion, Intravitreal injection of 6 million (MSCs) can retain the function of damaged photoreceptor cells in induced RP rabbits,so it presents a new hope for restoring the sight for RP patients

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Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.02.M.Sc.2017.Ah.R (Browse shelf(Opens below))		Not for loan		01010110073710000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.02.M.Sc.2017.Ah.R (Browse shelf(Opens below))	73710.CD	Not for loan		01020110073710000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry

Retinitis pigmentosa (RP) is a serious genetically eye disease which leads to blindness .The purpose of this study is to regenerate the damaged photoreceptor cells as a result of argon laser as a model of RP in rabbits' retina by using MSCs from rabbits' bone marrow. This study used MSCs in two doses (3 million and 6 million) to be injected intravitreal to regenerate the damaged cells. Determination of the level of (GSH, NO, MDA, CP, AGE and MMP-2) in blood and retina. Ophthalmological and histological examinations were performed on all rabbits. A significant increase of serum NO, plasma MDA and serum CP and decrease of blood GSH in argon laser group as compared to control group. While in (MSCs) groups NO, MDA and CP decreased and GSH increased. Outer and inner segments of photoreceptor cells began to reconstruct in histological examination in (MSCs) groups after complete detachment in argon laser group. 6 milion dose gave better results than 3 million. In conclusion, Intravitreal injection of 6 million (MSCs) can retain the function of damaged photoreceptor cells in induced RP rabbits,so it presents a new hope for restoring the sight for RP patients

Issued also as CD

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