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The effect of vitamin D supplementation on the pulmonary functions of adult asthmatic Egyptian patients / Amani Mohamed Mohamed Ali ; Supervised Nirmeen A. Sabry , Maggie Abbassi , Samah Selim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Amani Mohamed Mohamed Ali , 2017Description: 91 P. : charts , facsimiles ; 25cmOther title:
  • تأثير التكميل الغذائي بفيتامين(د) علي وظائف التنفس لمرضي الربو البالغين المصريين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Background: Despite the use of alfacalcidol in the management of corticosteroid-induced osteoporosis, it has never been thought of as an adjunct treatment for asthma management. It can target vitamin D deficiency, a possible risk factor for asthma and hence improves pulmonary functions of asthmatic patients. Objective: We aimed to explore the effect of alfacalcidol administration on the pulmonary functions of asthmatic adults in Egypt and study the pattern of vitamin D deficiency among them. Methods: Serum 25-hydroxyvitamin D₃ (25-OH D) was measured for hundred-fifteen adults: thirty-three healthy subjects and eighty-two asthmatic patients. Then, asthmatic patients were randomized to receive either standard asthma treatment only (N = 39) or receive it along with 1 microgram alfacalcidol daily for four months (N = 43). Randomization was stratified by the stage of asthma severity. Spirometry was carried out every two months. Measurement of 25-OH D and immunoglobulin E (IgE) was performed at baseline and end of follow-up. Results: Vitamin D deficiency was more common in asthmatic patients (57.3%) than in healthy subjects (21.2%, P < 0.001). In asthmatic patients, alfacalcidol significantly improved forced expiratory volume in first second (FEV1) as well as forced vital Capacity (FVC) (P < 0.001, both tests). Moreover, more patients in the intervention arm experienced improvement in asthma severity stage (P = 0.04). Non-significant difference was observed in FEV1 improvement between vitamin D deficient and indeficient patients in the intervention group (P > 0.05). Comparing severe and non-severe asthmatic patients, we find that the improvement in FEV₁ and FVC occurred earlier at 2 months of follow-up in severe asthmatic patients. Additionally, forced expiratory flow at 25-75% of the FVC (FEF ₂₅-₇₅%) was significantly increased in severe asthmatic patients only (P = 0.015)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Am.E (Browse shelf(Opens below)) Not for loan 01010110073905000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Am.E (Browse shelf(Opens below)) 73905.CD Not for loan 01020110073905000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Background: Despite the use of alfacalcidol in the management of corticosteroid-induced osteoporosis, it has never been thought of as an adjunct treatment for asthma management. It can target vitamin D deficiency, a possible risk factor for asthma and hence improves pulmonary functions of asthmatic patients. Objective: We aimed to explore the effect of alfacalcidol administration on the pulmonary functions of asthmatic adults in Egypt and study the pattern of vitamin D deficiency among them. Methods: Serum 25-hydroxyvitamin D₃ (25-OH D) was measured for hundred-fifteen adults: thirty-three healthy subjects and eighty-two asthmatic patients. Then, asthmatic patients were randomized to receive either standard asthma treatment only (N = 39) or receive it along with 1 microgram alfacalcidol daily for four months (N = 43). Randomization was stratified by the stage of asthma severity. Spirometry was carried out every two months. Measurement of 25-OH D and immunoglobulin E (IgE) was performed at baseline and end of follow-up. Results: Vitamin D deficiency was more common in asthmatic patients (57.3%) than in healthy subjects (21.2%, P < 0.001). In asthmatic patients, alfacalcidol significantly improved forced expiratory volume in first second (FEV1) as well as forced vital Capacity (FVC) (P < 0.001, both tests). Moreover, more patients in the intervention arm experienced improvement in asthma severity stage (P = 0.04). Non-significant difference was observed in FEV1 improvement between vitamin D deficient and indeficient patients in the intervention group (P > 0.05). Comparing severe and non-severe asthmatic patients, we find that the improvement in FEV₁ and FVC occurred earlier at 2 months of follow-up in severe asthmatic patients. Additionally, forced expiratory flow at 25-75% of the FVC (FEF ₂₅-₇₅%) was significantly increased in severe asthmatic patients only (P = 0.015)

Issued also as CD

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