Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction: The caustic ingestion continues to be a major problem worldwide especially in developing countries. The long-term complications include stricture and increased life time risk of esophageal carcinoma. Patients suffered from corrosive induced esophageal strictures have more than a 1000-fold risk of developing carcinoma of the esophagus. Aim of work: detect the possibility of esophageal mucosal dysplasia after prolonged dilatation of post corrosive esophageal stricture. To assess the relationship between duration since the corrosive ingestion and number of esophageal dilatation sessions with degree of esophageal mucosal dysplasia. Patients and methods: The work was carried out at the pediatric endoscopy unit in Cairo university children{u2019}s hospital. The study included the patients older than 2 years of age, of both sexes who had established diagnosis of post corrosive esophageal stricture on repeated endoscopic dilatation sessions for more than of six month duration. Infants below 2 year and other causes of esophageal stricture were excluded. Upper gastrointestinal endoscopic dilatation of esophageal stricture was done for all patients with biopsy from the stricture site. Histopathological examination of oesophageal mucosal biopsy was done for detection of chronic esophagitis, inflammatory cellular infiltration and dysplasia. The patients who had early grade dysplasia, were rebiopsied after period of time with the use of the chromoendoscopy by Lugol's iodine

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