Synthesis and biological evaluation of some novel thiazolidinone derivatives of anticipated chemotherapeutic activity / Mahmoud Farid Mahmoud Farid Aboashour ; Supervised Nagwa Mohamed Abdelgawad , Sahar Mahmoud Abouseri , Riham Francois George

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

The treatment of infectious diseases still remains an important and challenging problem because of a combination of factors including emerging infectious diseases and the increasing number of multi-drug resistant microbial pathogens with particular relevance for Gram negative bacteria and mycobacterium tuberculosis(TB). The World Health Organization (WHO) Tuberculosis Report indicates that TB is one of the world{u2019}s deadliest communicable diseases. In 2016, it estimates that there were 10.4 million new cases and 1.6 million deaths, including 390,000 deaths associated with co-infection. This therapeutic problem has achieved increasing importance in hospitalised patients, in immune suppressed patients with AIDS or undergoing anticancer therapy and organ transplants.Therefore, this work will focuses on design and synthesis of new anti-tubercular active agents with broad spectrum antimicrobial activity to address the problem of co-infection. In spite of a large number of antibiotics and chemotherapeutics available for treatment of TB, the emergence of resistance created a medical substantial need for new therapies.A potential approach to overcome the resistance problem is to design innovative agents with a different mode of action so that no cross resistance with the present therapeutics can occur.Therefore, this work is focused on synthesis of thirty-nine thiazolidenone hybrids and their evaluation against mycobacterium tuberculosis, some Gram positive, negative bacteria and fungi

Issued also as CD