Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

The prevalence of metabolic syndrome (MetS) has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. MetS is generally linked to complications in lipid metabolism, oxidative stress and low grade inflammation. The aim of the present study was to investigate the beneficial effect of rosuvastatin (Rosu) (10 mg/kg/day, po) and co-enzyme Q10 (CoQ10) (10 mg/kg/day, po) on MetS-induced oxidative stress in high fructose-high fat (HF-HFD) fed rats. Oral administration of Rosu, CoQ10 and a combination of them for 4 weeks along with (HF-HFD) elevated serum high density lipoprotein and the major antioxidant glutathione, decreased the serum levels of malondialdehyde, triglycerides, total cholesterol, low density lipoprotein-cholesterol as well as systolic blood pressure, body weight and fasting blood gulcose level .The pro-inflammatory mediators, namely tumor necrosis factor-Ü and interleukin-1Ý, declined. These preliminary results demonstrate that administration of Rosu, CoQ10 and combination of them can be beneficial for the suppression of obesity-induced oxidative stress, inflammation, hyperglycemia, hypertension and dyslipidemia in HF-HFD fed rats

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