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A pharmaceutical study on certain centrally acting drug / Mayada Said Mohamed Ahmed ; Supervised Ahmed Hassan Elshafeey , Ahmed Abdelfattah Aboelwafa , Ibrahim Elsayed Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mayada Said Mohamed Ahmed , 2017Description: 233 P. : charts ; 25cmOther title:
  • دراسة صيدلية على أحد أدوية الجهاز العصبى المركزى [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: Major depressive disorder (MDD) is the most common mood disorder. Depressive disorders are chronic and both relapse and recurrence are seen frequently. Agomelatine, a novel antidepressant drug, is a melatonin analogue with a potent agonistic action on melatonin MT1 and MT2 receptors. It also has serotonin 5-HT2C receptor antagonistic activity. Although agomelatine is rapidly and well absorbed ( >75%) after oral administration, it is subjected to an extensive hepatic first pass metabolism leading to a low absolute bioavailability ( <5%). Moreover, it has a liver toxicity as it raises liver transaminase enzymes. The oral dose of agomelatine is 25 to 50 mg daily. The aim of this study was to deliver agomelatine through transdermal route and to reduce its dose (hence increasing its absolute bioavilablity). The work in this thesis is divided into three chapters as follows: Chapter 1: Formulation and optimization of agomelatine microemusions using D-optimal mixture design. Chapter 2: Formulation and optimization of agomelatine cubosomes using Box behnken design. Chapter 3: Bioavailability study of agaomelatine optimum microemusion gel formula and cubosomal formula. Chapter 1: Formulation and optimization of agomelatine MEs using D-optimal mixture design. Microemulsions are optically isotropic and thermodynamically stable systems consisting of oil, water, surfactants and cosurfactant. Preliminary screening was carried out to select proper ingredients combinations and then, the design expert software was utilized to optimize the microemulsion formulations. The independent variables of the employed mixture design were capryol 90 as an oily phase (X₁), cremophor RH40 and transcutol HP in a ratio of (1:2) as Smix (X₂) and water (X₃). The dependent variables were globule size, optical clarity, Q₁, Q₂₄ and ER
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Ma.P (Browse shelf(Opens below)) Not for loan 01010110074118000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2017.Ma.P (Browse shelf(Opens below)) 74118.CD Not for loan 01020110074118000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Major depressive disorder (MDD) is the most common mood disorder. Depressive disorders are chronic and both relapse and recurrence are seen frequently. Agomelatine, a novel antidepressant drug, is a melatonin analogue with a potent agonistic action on melatonin MT1 and MT2 receptors. It also has serotonin 5-HT2C receptor antagonistic activity. Although agomelatine is rapidly and well absorbed ( >75%) after oral administration, it is subjected to an extensive hepatic first pass metabolism leading to a low absolute bioavailability ( <5%). Moreover, it has a liver toxicity as it raises liver transaminase enzymes. The oral dose of agomelatine is 25 to 50 mg daily. The aim of this study was to deliver agomelatine through transdermal route and to reduce its dose (hence increasing its absolute bioavilablity). The work in this thesis is divided into three chapters as follows: Chapter 1: Formulation and optimization of agomelatine microemusions using D-optimal mixture design. Chapter 2: Formulation and optimization of agomelatine cubosomes using Box behnken design. Chapter 3: Bioavailability study of agaomelatine optimum microemusion gel formula and cubosomal formula. Chapter 1: Formulation and optimization of agomelatine MEs using D-optimal mixture design. Microemulsions are optically isotropic and thermodynamically stable systems consisting of oil, water, surfactants and cosurfactant. Preliminary screening was carried out to select proper ingredients combinations and then, the design expert software was utilized to optimize the microemulsion formulations. The independent variables of the employed mixture design were capryol 90 as an oily phase (X₁), cremophor RH40 and transcutol HP in a ratio of (1:2) as Smix (X₂) and water (X₃). The dependent variables were globule size, optical clarity, Q₁, Q₂₄ and ER

Issued also as CD

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