Clinical role of micro-rnas expression in acute myeloid leukemia : miR-155, miR-424 deregulation, correlation With NPM1 / Reem Mohamed Ahmed Embaby ; Supervised Laila Abdelrahman Hegazy , Hanan Ramadan Nassar , Nohair Soliman
Material type:
- الدور الاكلينيكي للتعبير عن الحامض النووي الريبي الدقيق بنوعيه 155 و 424 في حالات سرطان الدم الميلودي الحاد وعلاقته مع جين النيكليوفوزمين [Added title page title]
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Item type | Current library | Home library | Call number | Copy number | Status | Barcode | |
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قاعة الرسائل الجامعية - الدور الاول | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.11.07.Ph.D.2017.Re.C (Browse shelf(Opens below)) | Not for loan | 01010110074216000 | ||
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مخـــزن الرســائل الجـــامعية - البدروم | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.11.07.Ph.D.2017.Re.C (Browse shelf(Opens below)) | 74216.CD | Not for loan | 01020110074216000 |
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Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
AML is a highly heterogeneous disease characterized by failure of myeloid precursor cells to undergo terminal differentiation from proliferating precursor cells into mature blood cells. MicroRNAs (miRNAs) are small, non-coding RNAs control the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells and tumorigenesis. The study aimed to clarify role of miR-155,mir-424,in pathogenesis ,prognosis of AML and correlation of both miRNAs with NPM1 gene .The present study done on 40 adult newly diagnosed AML cases that were taken from National Cancer Inistitute & medical oncology unit Kasr Aini School of Medicine, Cairo University and 40 sex & age matched controls. A quantitative reverse-transcription PCR (qRT-PCR) assay was done to relatively quantify miR-424,miR-155. (RT-PCR) assay was done to assess NPM1 mutation and correlate it with both micro-RNAs.There was highly statistically significant difference in miR-424 between both patients and controls (p=0.0001),miR 155 was a bad predictor for AML cases. No correlation was found between miR -424, miR-155 and NPM1 .So that deregulated expression of both miRNAs does not depend on NPM1 to exhibit its role in leukemogenesis
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