Short course versus standard course of radiotherapy in glioblastoma multiforme / Ibrahim Mohamed Sherif Elzawahry ; Supervised May Hussein Gaber, Amr Yehia Sakr , Dina Hussieny Salama

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Ibrahim Mohamed Sherif Elzawahry

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TextLanguage: English Publication details: Cairo : Ibrahim Mohamed Sherif Elzawahry , 2017Description: 136 P. : charts , facsimiles ; 25cmOther title:

دراسة مقارنه بين عدد جلسات العلاج الإشعاعي التقليدي وعدد جلسات العلاج الإشعاعي قصيرة المدة في علاج الحالات المصابة بورم أرومي دبقي بالمخ [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Oncology (Clinical ) Summary: To perform a subset analysis of survival outcomes in patients with glioblastoma (GBM) from a randomized trial comparing short-course radiotherapy (RT) regimens with standard course. Methods and Materials Patients joined the randomized, multicenter, prospective trial and were assigned to one of two groups in a 1:1 ratio to either short-course RT (40 Gy in 15 fractions, arm 1) or standard course RT (60 Gy in 30 fractions, arm 2) with concurrent temozolomide and adjuvant temozolomide for 6 months. patients were stratified by Age, performance status, and extent of surgery. Results In this analysis, the short-course RT results were not statistically significant different to standard course RT. The median overall survival time was 13.7months (95% CI, 4.5 to 9.1 months) in arm 1 and 15 months (95% CI, 8.5 to 22.0 months) in arm 2 (P = 0.936). Median progression-free survival time was 12 months (95% CI: 8.2-15.7) in arm 1 and 12.8 months (95% CI: 7.96-17.63) in arm 2 (P = 0.706). Conclusions A short-course RT regimen of 40 Gy in 15 fractions is an acceptable treatment option for patients with glioblastomamultiforme, in order to reduce cost and the machine overload in view of non-significant difference in survival, toxicity and response rate compared to standard course

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.23.Ph.D.2017.Ib.S (Browse shelf(Opens below))		Not for loan		01010110074292000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.23.Ph.D.2017.Ib.S (Browse shelf(Opens below))	74292.CD	Not for loan		01020110074292000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Oncology (Clinical )

To perform a subset analysis of survival outcomes in patients with glioblastoma (GBM) from a randomized trial comparing short-course radiotherapy (RT) regimens with standard course. Methods and Materials Patients joined the randomized, multicenter, prospective trial and were assigned to one of two groups in a 1:1 ratio to either short-course RT (40 Gy in 15 fractions, arm 1) or standard course RT (60 Gy in 30 fractions, arm 2) with concurrent temozolomide and adjuvant temozolomide for 6 months. patients were stratified by Age, performance status, and extent of surgery. Results In this analysis, the short-course RT results were not statistically significant different to standard course RT. The median overall survival time was 13.7months (95% CI, 4.5 to 9.1 months) in arm 1 and 15 months (95% CI, 8.5 to 22.0 months) in arm 2 (P = 0.936). Median progression-free survival time was 12 months (95% CI: 8.2-15.7) in arm 1 and 12.8 months (95% CI: 7.96-17.63) in arm 2 (P = 0.706). Conclusions A short-course RT regimen of 40 Gy in 15 fractions is an acceptable treatment option for patients with glioblastomamultiforme, in order to reduce cost and the machine overload in view of non-significant difference in survival, toxicity and response rate compared to standard course

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