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Tumor budding cytokeratin- detection and expression of matrix metalloproteinase-2 in invasive duct carcinoma of the breast histopathological and immunohistochemical study / Mohamed Emam Mohamed Sedqi ; Supervised Ahmed Mahmoud Abdelaziz , Samia Mohamed Gabal , Amira Mohamed Bassam

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Emam Mohamed Sedqi , 2017Description: 105 P. : charts , facsimiles ; 25cmOther title:
  • الكشف عن التبرعم الورمي بإستخدام السيتوكيراتين و التعبير عن ميتالوبروتينيز-2 في سرطان قنوات الثدي الغزوي دراسة هيستوباثولوجية ومناعية كيميائية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology Summary: Breast cancer is the most frequently diagnosed cancer worldwide, and the leading cause of cancer death in females. Tumor budding was defined as the presence of clusters of undifferentiated malignant cells; single cell to a cluster of {u2264}5 cells located in close proximity to the invasive front of a tumor. Over-expression of MMPs was found to be important for tumor invasion and metastasis. The current study evaluated tumor budding using cytokeratin immunostaining and expression of MMP-2 in 61 cases of breast invasive duct carcinoma. A significant positive correlation was found between tumor budding and breast duct carcinoma NST-type, tumor ill-defined borders, positive lymph metastasis and high proliferation rate, and when budding is combined with positive MMP-2 expression in both tumor cells and stoma; there is significant correlation with estrogen expression and flushed resection margin status. Larger studied with larger sample sizes and patients follow up are needed to document the feasibility of utilizing tumor budding assessment in putting strategies for patient management
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2017.Mo.T (Browse shelf(Opens below)) Not for loan 01010110074516000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.27.Ph.D.2017.Mo.T (Browse shelf(Opens below)) 74516.CD Not for loan 01020110074516000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology

Breast cancer is the most frequently diagnosed cancer worldwide, and the leading cause of cancer death in females. Tumor budding was defined as the presence of clusters of undifferentiated malignant cells; single cell to a cluster of {u2264}5 cells located in close proximity to the invasive front of a tumor. Over-expression of MMPs was found to be important for tumor invasion and metastasis. The current study evaluated tumor budding using cytokeratin immunostaining and expression of MMP-2 in 61 cases of breast invasive duct carcinoma. A significant positive correlation was found between tumor budding and breast duct carcinoma NST-type, tumor ill-defined borders, positive lymph metastasis and high proliferation rate, and when budding is combined with positive MMP-2 expression in both tumor cells and stoma; there is significant correlation with estrogen expression and flushed resection margin status. Larger studied with larger sample sizes and patients follow up are needed to document the feasibility of utilizing tumor budding assessment in putting strategies for patient management

Issued also as CD

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