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Urinary podocalyxin as an early marker in diabetic nephropathy / Mohammed Mosad Fahim Eissa ; Supwervised Omar Ahmed Mokhtar Elsaadany , Hany Abdelrahman Saeed Hammad , Dina Hesham Ahmed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohammed Mosad Fahim Eissa , 2017Description: 130 P. : charts , facsimiles ; 25cmOther title:
  • دراسة وجود بروتين البودوكالكسين في البول و دوره الحيوي في الاكتشاف المبكر لاعتلال الكلى بسبب مرض السكري [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Introduction Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Early identification of nephropathy in diabetes patients is crucial because it creates opportunity for preventing the incidence of DN and/or even slows down the process of end-stage renal disease attributed to diabetes. Human podocytes (Pods) have been demonstrated to be functionally and structurally injured in the natural history of diabetic nephropathy. Podocalyxin (PCX) is the major surface antigen of podocytes and the expression of PCX on podocytes remains unchanged in various kinds of glomerular nephritis. Aim Of Work To evaluate the possible association between the urinary podocalyxin levels and severity and grade of diabetic nephropathy. To use URINARY PODOCALYXIN as a non-invasive marker for early stage of Diabetic Nephropathy. Patients And Method 25 patients were collected from ALSAHEL TEACHING HOSPITAL , diagnosed as diabetic nephropathy in microalbuminuria and macroalbuminuria stages . 25 apparently healthy volunteers will included as a control group. For every patient full history taking , clinical evaluation and fundus examination were done. Labs (serum creatinine , blood urea , calcium , phosphorus , albumin ,HbA1C, complete urine analysis , albumin creatinine ratio , urinary podocalyxin ) were done. Results We found that podocalyxin is significantly increased in micro and macralbuminuric groups compared to normal , also increased significantly in macroalbuminuric group compared to microalbuminuric group. Conclusion URINARY PODOCALYXIN can be used as a non-invasive marker for early stage of Diabetic Nephropathy
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2017.Mo.U (Browse shelf(Opens below)) Not for loan 01010110074523000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2017.Mo.U (Browse shelf(Opens below)) 74523.CD Not for loan 01020110074523000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Introduction Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Early identification of nephropathy in diabetes patients is crucial because it creates opportunity for preventing the incidence of DN and/or even slows down the process of end-stage renal disease attributed to diabetes. Human podocytes (Pods) have been demonstrated to be functionally and structurally injured in the natural history of diabetic nephropathy. Podocalyxin (PCX) is the major surface antigen of podocytes and the expression of PCX on podocytes remains unchanged in various kinds of glomerular nephritis. Aim Of Work To evaluate the possible association between the urinary podocalyxin levels and severity and grade of diabetic nephropathy. To use URINARY PODOCALYXIN as a non-invasive marker for early stage of Diabetic Nephropathy. Patients And Method 25 patients were collected from ALSAHEL TEACHING HOSPITAL , diagnosed as diabetic nephropathy in microalbuminuria and macroalbuminuria stages . 25 apparently healthy volunteers will included as a control group. For every patient full history taking , clinical evaluation and fundus examination were done. Labs (serum creatinine , blood urea , calcium , phosphorus , albumin ,HbA1C, complete urine analysis , albumin creatinine ratio , urinary podocalyxin ) were done. Results We found that podocalyxin is significantly increased in micro and macralbuminuric groups compared to normal , also increased significantly in macroalbuminuric group compared to microalbuminuric group. Conclusion URINARY PODOCALYXIN can be used as a non-invasive marker for early stage of Diabetic Nephropathy

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