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Comparative study between different laboratory methods in the diagnosis of human brucellosis / Sara Elhossain Aly Reda Mohamed ; Supervised Mona Abdelwahab Abdelmessih , Abdelmeguid Kassem , Lamiaa Abdelfattah Ahmed Madkour

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sara Elhossain Aly Reda Mohamed , 2017Description: 137 P. : charts , facsimiles ; 25cmOther title:
  • دراسة مقارنة للطرق المعملية المختلفه لتشخيص مرض الحمى المالطيه فى الانسان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology Summary: The aim of the study was to compare the performance of different serological tests in the diagnosis of brucellosis, considering quantitative real time PCR (qPCR) as the reference test. Quantitative real time PCR was positive for Brucella DNA in 65% out of 100 serum samples. Both the standard tube agglutination test (STAT) and rose bengal (RB) test revealed high sensitivity in the detection of brucellosis (95% and 89% respectively). The positive predictive value (PPV) of STAT was 65%, while RB and ELISA had the same PPV (64%). On the other hand, the negative predictive values were 40%, 22% and 33% for STAT, RB and ELISA respectively. However, the specificity of both STAT and RB was surprisingly low (6%). On the other hand, ELISA had a sensitivity of 75% and a specificity of 23%. These results highlight the value of ELISA as a rapid and reliable tool for the diagnosis of brucellosis particularly in endemic areas
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.19.Ph.D.2017.Sa.C (Browse shelf(Opens below)) Not for loan 01010110074578000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.19.Ph.D.2017.Sa.C (Browse shelf(Opens below)) 74578.CD Not for loan 01020110074578000
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Cai01.11.19.Ph.D.2017.Re.A Association of serum IL-6 Level and its -174 G/C promoter polymorphism with clinical and laboratory characteristics of rheumatoid arthritis patients in Cairo University Hospitals / Cai01.11.19.Ph.D.2017.Re.A Association of serum IL-6 Level and its -174 G/C promoter polymorphism with clinical and laboratory characteristics of rheumatoid arthritis patients in Cairo University Hospitals / Cai01.11.19.Ph.D.2017.Sa.C Comparative study between different laboratory methods in the diagnosis of human brucellosis / Cai01.11.19.Ph.D.2017.Sa.C Comparative study between different laboratory methods in the diagnosis of human brucellosis / Cai01.11.19.Ph.D.2018.Ah.M Multiplex PCR for detection of five selected carbapenemase genes in comparative study with modified-hodge test in gram-negative bacilli isolated from healthcare-associated infections among critically Ill patients / Cai01.11.19.Ph.D.2018.Ah.M Multiplex PCR for detection of five selected carbapenemase genes in comparative study with modified-hodge test in gram-negative bacilli isolated from healthcare-associated infections among critically Ill patients / Cai01.11.19.Ph.D.2018.As.A Assessment of the potential effect of Epstein-Barr Virus concomitant infection on the response to Interferon-Ribavirin therapy among chronic Hepatitis C Virus infected patients /

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology

The aim of the study was to compare the performance of different serological tests in the diagnosis of brucellosis, considering quantitative real time PCR (qPCR) as the reference test. Quantitative real time PCR was positive for Brucella DNA in 65% out of 100 serum samples. Both the standard tube agglutination test (STAT) and rose bengal (RB) test revealed high sensitivity in the detection of brucellosis (95% and 89% respectively). The positive predictive value (PPV) of STAT was 65%, while RB and ELISA had the same PPV (64%). On the other hand, the negative predictive values were 40%, 22% and 33% for STAT, RB and ELISA respectively. However, the specificity of both STAT and RB was surprisingly low (6%). On the other hand, ELISA had a sensitivity of 75% and a specificity of 23%. These results highlight the value of ELISA as a rapid and reliable tool for the diagnosis of brucellosis particularly in endemic areas

Issued also as CD

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