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Role of radiotherapy following surgical resection with curative intent for patients with stage IB-III gastric cancer - The NCI Cairo experience : A retrospective study 2009-2015 / Salma Kamal Abdelhamid Eissa ; Supervised Mohammed Abdallah , Azza Mohammed Nasr , Sherweif Mohammed Abdelfattah

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Salma Kamal Abdelhamid Eissa , 2017Description: 115 P. : charts , fcsimiles ; 25cmOther title:
  • أهمية العلاج الاشعاعي لحالات سرطان المعدة من المرحلة الاولى الى الثالثة بعد الاستئصال الجذرى للورم : دراسة استرجاعية بالمعهد القومي للأورام2009-2015 [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Oncology (Clinical) Summary: Background The mainstay of treatment for potentially curable gastric carcinoma is radical gastrectomy. However, surgery alone is not a sufficient treatment for most gastric cancer patients, leading to poor long term survival and high incidence of locoregional recurrences. Several multimodality therapies have shown improvement in outcome compared to surgery alone. This restrospective study investigates the impact of adding adjuvant radiotherapy on locoregional control, overall survival and disease free survival in comparison to other treatment modalities not including radiotherapy. Methods Data of 79 patients with stage IB-III gastric cancer who underwent radical gastrectomy with curative intent at NCI during the period (2009-2015) were collected, analysed and followed up until 8/2017. The patients were split into two groups; Group A including patients who received adjuvant chemoradiotherapy, and Group B which includes patients who did not receive radiotherapy in their course of treatment. The locoregional control (LRC), overall survival (OS) and disease free survival (DFS) were compared for both groups, as was treatment related toxicity. Results Adjuvant chemoradiotherapy significantly improved locoregional control, overall survival and disease free survival. Patients in Group A had a median LRC of 30 months in comparison to 20 months in Group B (p=0.021). Median OS was 39 months and 29 months for Group A and Group B respectively (p=0.02). DFS was also significantly better in Group A than Group B (p=0.001). Treatment related toxicity, however, was higher in Group A. Conclusion Patients with stage IB-III potentially curable gastric cancer benefit significantly from adding adjuvant radiotherapy following radical gastrectomy; in terms of improved survival and reduction of risk of locoregional recurrence
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.23.M.Sc.2017.Sa.R (Browse shelf(Opens below)) Not for loan 01010110074681000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.23.M.Sc.2017.Sa.R (Browse shelf(Opens below)) 74681.CD Not for loan 01020110074681000
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Cai01.11.23.M.Sc.2017.Sa.C Clinico-epidemiological profile of endometrial carcinoma in Kasr Alainy center of clinical oncology and nuclear Medicine and Fayoum university Hospital and treatment outcomes from January 2012 till December 2016 / Cai01.11.23.M.Sc.2017.Sa.C Clinico-epidemiological profile of endometrial carcinoma in Kasr Alainy center of clinical oncology and nuclear Medicine and Fayoum university Hospital and treatment outcomes from January 2012 till December 2016 / Cai01.11.23.M.Sc.2017.Sa.R Role of radiotherapy following surgical resection with curative intent for patients with stage IB-III gastric cancer - The NCI Cairo experience : A retrospective study 2009-2015 / Cai01.11.23.M.Sc.2017.Sa.R Role of radiotherapy following surgical resection with curative intent for patients with stage IB-III gastric cancer - The NCI Cairo experience : A retrospective study 2009-2015 / Cai01.11.23.M.Sc.2017.Yo.C Comparative study of impact of HCV infection on the treatment outcome of patients with non hodgkin's lymphoma / Cai01.11.23.M.Sc.2017.Yo.C Comparative study of impact of HCV infection on the treatment outcome of patients with non hodgkin's lymphoma / Cai01.11.23.M.Sc.2018.Ah.T Treatment outcome of patients with carcinoma of vulva NCI Cairo experience /

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Oncology (Clinical)

Background The mainstay of treatment for potentially curable gastric carcinoma is radical gastrectomy. However, surgery alone is not a sufficient treatment for most gastric cancer patients, leading to poor long term survival and high incidence of locoregional recurrences. Several multimodality therapies have shown improvement in outcome compared to surgery alone. This restrospective study investigates the impact of adding adjuvant radiotherapy on locoregional control, overall survival and disease free survival in comparison to other treatment modalities not including radiotherapy. Methods Data of 79 patients with stage IB-III gastric cancer who underwent radical gastrectomy with curative intent at NCI during the period (2009-2015) were collected, analysed and followed up until 8/2017. The patients were split into two groups; Group A including patients who received adjuvant chemoradiotherapy, and Group B which includes patients who did not receive radiotherapy in their course of treatment. The locoregional control (LRC), overall survival (OS) and disease free survival (DFS) were compared for both groups, as was treatment related toxicity. Results Adjuvant chemoradiotherapy significantly improved locoregional control, overall survival and disease free survival. Patients in Group A had a median LRC of 30 months in comparison to 20 months in Group B (p=0.021). Median OS was 39 months and 29 months for Group A and Group B respectively (p=0.02). DFS was also significantly better in Group A than Group B (p=0.001). Treatment related toxicity, however, was higher in Group A. Conclusion Patients with stage IB-III potentially curable gastric cancer benefit significantly from adding adjuvant radiotherapy following radical gastrectomy; in terms of improved survival and reduction of risk of locoregional recurrence

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