Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Orthopedic Surgery

Background: Spinal tuberculosis occurs in less than 1% of patients with TB (2, 3), but the increasing frequency of TB in both developed and developing countries have continued to make spinal TB a health problem (2). Spinal TB (Pott{u2019}s disease) is the most common as well as one of the most dangerous forms of skeletal TB and accounts for 50% of all cases of skeletal TB. Mainly in the thoracolumbar area (1). Methods: FromJuly 2015 to December 2016, 20 patients with suspected spinal thoraco-lumbar tuberculosis treated by isolated posterior debridement and fixation and followed up for 12 months with anti TB chemotherapy. The mean age of patients was 41.10 (SD ±13.28) years. Clinical assessment by ambulatory status (AS), Visual analogue scale (VAS) score, american spinal Injury association (ASIA) impairment scale. Radiological assessment: Posterior and anterior vertebral height, segmental, local sagittal angle and bony fusion. Laboratory assessment: ESR, CRP were evaluated. Results: Post-operative radiological assessment showed that the mean sagittal segmental anglecorrection from 24.5{u00BA} to 8.55{u00BA}, and the mean sagittal local angle correction from 22.55{u00BA} to 7.9{u00BA}. The mean anterior vertebral body height was 3.08 cmchanged to 3.9 cm. The mean posteriorvertebral body height was 4.05 cmimproved to 4.54 cm. bony fusion achieved in 75% patients within one year FU. Post-operative clinical assessment showed that the mean VAS score of the patients were decreased from 5.3 before surgery to 0.55 at one year FU and neurological condition in all patients improved after surgery

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