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Study on IL28B SNP rs12979860 and SNP rs8099917 genotyping and treatment response with pegylated Interferon and ribavirin in Egyptian patients with chronic hepatitis C virus infection / Esmail Qasem Mohammed Elhitty ; Supervised Nouman M. Elgarem , Mona Ahmed Amin , Dina Sabry Abdelfatah

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Esmail Qasem Mohammed Elhitty , 2017Description: 170 P. : charts ; 25cmOther title:
  • تقييم مدى العلاقة بين التغيرات الجينية فى الإنترليوكين (ب 28) و مدى استجابة المرضى المصريين للعلاج الدوائى للالتهاب الكبدى الفيروسى (س) المزمن [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine Summary: Introduction: For SNP rs8099917, the favorable T allele is associated with a higher SVR after PEG-IFN alpha/RBV therapy while the G allele is a risk factor for non-response. Aim of the work: Is to assess the value of (SNP) rs8099917 as a predictor of SVR. Methods: This study is a retrospective controlled study and was performed on a total number of 604 patients who were treated by PEG-IFN alpha/RBV for 48 weeks and (SNP) rs8099917 was done for the all patients. Results: TT genotype was more prevalent in SVR group than TG and GG genotypes. Conclusion: Determination of (SNP) rs8099917 before starting antiviral therapy may thus serve as a good response predictor
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2017.Es.S (Browse shelf(Opens below)) Not for loan 01010110074922000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.Ph.D.2017.Es.S (Browse shelf(Opens below)) 74922.CD Not for loan 01020110074922000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Introduction: For SNP rs8099917, the favorable T allele is associated with a higher SVR after PEG-IFN alpha/RBV therapy while the G allele is a risk factor for non-response. Aim of the work: Is to assess the value of (SNP) rs8099917 as a predictor of SVR. Methods: This study is a retrospective controlled study and was performed on a total number of 604 patients who were treated by PEG-IFN alpha/RBV for 48 weeks and (SNP) rs8099917 was done for the all patients. Results: TT genotype was more prevalent in SVR group than TG and GG genotypes. Conclusion: Determination of (SNP) rs8099917 before starting antiviral therapy may thus serve as a good response predictor

Issued also as CD

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