Evaluation of cervical crown/root fracture following PRF revascularization versus root canal treatment of non-vital anterior permanent teeth with closed apex : Randomized clinical trial = تقيم كسر الاسنان من منطقة عنق التاج أو الجذر بعد عودة التوعى باستخدام الصفائح الدموية الغنية بالليفين ازاء علاج الجذور لأسنان الدائمة الغير حية بقمة جذر مقفلة : تجربة اكلينيكية عشوائية / Mohamed Nageh Tawfik ; Supervised Khaled Mohamed Ezzat , Geraldine Mohamed Ahmed

Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Endodontics

Preservation of the natural dentition remains a primary objective in endodontic practice. When the pulp is diseased or necessitates removal for restorative reasons, it can be replaced with an artificial filling material. Esthetics, form and function are not primarily dependent upon a vital pulp after root maturation, but there are disadvantages to conventional root canal treatment. It has been suggested that endodontically treated teeth dry out over time and that the dentin in endodontically treated teeth undergoes changes in collagen cross-linking. Therefore, it has been suggested that endodontically treated teeth are more brittle and may fracture more easily than non-endodontically treated teeth. That shed light for new treatment modalities as regenerative endodontic treatment. Regenerative endodontic treatment requires three main components; stem cells, scaffold and signaling molecules. But a sterile medium is the corner stone for the treatment to succeed. There is no strict clinical protocol to follow due to the lack of abundant clinical trials in the literature. This study was conducted to test the efficacy of using the second generation of platelet concentrates; platelet rich fibrin (PRF) in the revascularization process. As PRF was known to contain growth factors which help in angiogenesis, neurogenesis, dentinogenesis, and osteogenesis

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