Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Inorganic Chemistry

The complex formation reactions of [Pd(MAMP)(H₂O)₂]²⁺ (MAMP = 2-[(methylamino)methyl]pyridine) with some selected bio-relevant ligands, containing different functional groups, were investigated. The ligands used are dicarboxylic acids, amino acids, peptides and DNA constituents. Stoichiometry and stability constants of the complexes formed are reported at 25 oC and 0.1M ionic strength. The results show the formation of 1:1 complexes with amino acids and dicarboxylic acids. The effect of chelate ring size of the dicarboxylic acid complexes on their stability constants is examined. Peptides form both 1:1 complexes and the corresponding deprotonated amide species. DNA constituents form 1:1 and 1:2 complexes. Both DNA constituents and cyclobutane dicarboxylic acid (CBDCA) react with [Pd(MAMP)(H2O)2]2+ forming [Pd(MAMP)(CBDCA-O)DNA], where (CBDCA-O) represents cyclobutanedicarboxylate coordinated by one carboxylate oxygen atom. The concentration distribution of the complexes in solution is evaluated. The equilibrium constant of the displacement reaction of coordinated inosine, as a typical DNA constituent, by S-methylcysteine, as a typical thiol ligand was investigated. The effect of dioxane on the acid dissociation constants of CBDCA and the formation constant of its complex with Pd(MAMP)²⁺ was reported. The thermodynamic parameters for the interaction of [Pd(MAMP)(H₂O)₂]²⁺ were calculated and discussed

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