Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Surgery

Objectives: The aim of this study is to verify whether there is a significant difference in clinical outcomes between locking and non-locking miniplate fixation in the management of mandibular fractures. Materials and methods: Systematic and electronic searches through databases, hand searching of relevant scientific journals, reference lists of all trials identified were checked as well as manual search in Cairo, Ain Shams, and Alexandria universities were conducted (till 11th March 2017). The following databases were searched was applied to pub Med (to 2nd of March 2017), The cochrane library (cochrane database of systematic reviews) (to 4th of March 2017), web of science (science/social sciences citation index) (to 1st of March 2017), we finished our search on (11th of March 2017). Inclusion criteria of the studies were clinical human studies, randomized clinical trial, non-randomized clinical trials, cohort studies, cross-section studies and case series which compared the use of locking and non-locking miniplate fixation techniques in the management of mandibular fractures. Search was restricted in the English language, without date restrictions were performed in March 2017, for published and unpublished papers. Result: the search retrieved 1000 studies, only twenty of which met our inclusion criteria (fourteen RCTs, five studies non-RCT and one study was a retrospective cohort study), 858 patients with 1027 fracture sites enrolled into the analysis. We used (OR) together with 95% confidence intervals (CIs) to calculate the estimate of the effect of an intervention, Heterogeneity was measured by the I ² index

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