header
Image from OpenLibrary

Effect of an anti-inflammatory drug on the level of expression of some oncogenic proteins in breast cancer in vitro tissue culture model / Nadia Abdelnaby Thabet ; Supervised Mona Mostafa Mohamed , Samia A. Shouman , Nadia Mohamed Elguendy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nadia Abdelnaby Thabet , 2017Description: 127 P. : photographs ; 25cmOther title:
  • تأثير العقار المضاد للالتهاب على التغير فى مستوى بروتينات سرطانية فى نموذج خارحى لزراعه نسيج سرطان الثدى [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Tumor associated macrophages (TAMs) provide the tumor microenvironment with multiple inflammatory mediators to stimulate several intrinsic pathways, consequently they have a crucial role in cancer progression and metastasis and therapeutic response. Although the role of non steroidal anti-inflammatory drugs (NSAIDs) in prevention of cancer incidence and progression has been documented in several types of cancer, its role in suppression the interactions between TAMs and cancer cells remain unclear. The aim of the present study was to determine the contribution of secretions of TAMs to breast cancer progression through intrinsic events, such as modulation of Ras and Par-4 expression, and stimulation of inflammatory mediators production such as IL-1Ý, IL-6, Cox-2 and PGE2 which found to be highly expressed in more than 40% of breast cancer patients. Furthermore, we examined the mechanism by which NSAIDs (sulindac sulfide and piroxicam) suppress the progression of stimulated breast cancer cells. In present study media conditioned by U937 human monocytes (U937-CM) were used to stimulate MCF-7 and MDA-MB-231 human breast cancer cells, we determined the tumor promoting activity of U937-CM on MCF-7 and MDA-MB-231 cells
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2017.Na.E (Browse shelf(Opens below)) Not for loan 01010110075059000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2017.Na.E (Browse shelf(Opens below)) 75059.CD Not for loan 01020110075059000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Tumor associated macrophages (TAMs) provide the tumor microenvironment with multiple inflammatory mediators to stimulate several intrinsic pathways, consequently they have a crucial role in cancer progression and metastasis and therapeutic response. Although the role of non steroidal anti-inflammatory drugs (NSAIDs) in prevention of cancer incidence and progression has been documented in several types of cancer, its role in suppression the interactions between TAMs and cancer cells remain unclear. The aim of the present study was to determine the contribution of secretions of TAMs to breast cancer progression through intrinsic events, such as modulation of Ras and Par-4 expression, and stimulation of inflammatory mediators production such as IL-1Ý, IL-6, Cox-2 and PGE2 which found to be highly expressed in more than 40% of breast cancer patients. Furthermore, we examined the mechanism by which NSAIDs (sulindac sulfide and piroxicam) suppress the progression of stimulated breast cancer cells. In present study media conditioned by U937 human monocytes (U937-CM) were used to stimulate MCF-7 and MDA-MB-231 human breast cancer cells, we determined the tumor promoting activity of U937-CM on MCF-7 and MDA-MB-231 cells

Issued also as CD

There are no comments on this title.

to post a comment.