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Biochemical study of liver toxicity during treatment with different drugs formulae containing glucosamine-chondroitin in male albino rats / Elshaymaa Aboubakr Zein Elabedin Ibrahim ; Supervised Mohi A. F. Sharaf , Mohamed A. Eldesouky , Aida M. Saad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Elshaymaa Abou Bakr Zein El Abedin Ibrahim , 2016Description: 132 P. : charts , facsimiles ; 25cmOther title:
  • دراسة كيميائية حيوية للتسمم الكبدى أثناء العلاج بعقاقير مختلفة ذات تركيبات تحتوى على جلوكوزامين {u٢٠١٣} كوندرويتين فى ذكور الجرذان [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: The present study investigated the effect of three different products containing glucosamine (a, b and c) that are extensively used in the treatment of osteoarthritis against carbon tetrachloride (CCl4) induced liver injury in male albino rats. The investigated effects were compared with the effect of a reference antioxidant drug (d). The degree of the studied effects was evaluated by determination of serum levels of (ALT, AST, total cholesterol, triglycerides, total protein and albumin), and liver tissue content of (MDA, NO, GSH and GSSG). Histopathological examination was performed to provide direct evidences of hepatotoxicity, hepatoprotective and curative effects of the tested nutraceuticals. The present study concluded that a, b and c may play protective and curative roles against CCl4-induced liver damage in rats which may be due to their antioxidant activities. The formulae a and c showed more potency than b as compared with the potency of d. a- Move free advanced plus MSM b- Glucosamine plus Vit. D c- Glucosamine Triple Strength d- Liverin
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2016.El.B (Browse shelf(Opens below)) Not for loan 01010110075053000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2016.El.B (Browse shelf(Opens below)) 75053.CD Not for loan 01020110075053000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

The present study investigated the effect of three different products containing glucosamine (a, b and c) that are extensively used in the treatment of osteoarthritis against carbon tetrachloride (CCl4) induced liver injury in male albino rats. The investigated effects were compared with the effect of a reference antioxidant drug (d). The degree of the studied effects was evaluated by determination of serum levels of (ALT, AST, total cholesterol, triglycerides, total protein and albumin), and liver tissue content of (MDA, NO, GSH and GSSG). Histopathological examination was performed to provide direct evidences of hepatotoxicity, hepatoprotective and curative effects of the tested nutraceuticals. The present study concluded that a, b and c may play protective and curative roles against CCl4-induced liver damage in rats which may be due to their antioxidant activities. The formulae a and c showed more potency than b as compared with the potency of d. a- Move free advanced plus MSM b- Glucosamine plus Vit. D c- Glucosamine Triple Strength d- Liverin

Issued also as CD

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