Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Objective:This study is meant to evaluate clinically and radiographically the possible predictable results regarding the use of amnion chorion allograft barrier, versus the use of allograft bone putty in the treatment of periodontal intrabony defects. Materials and methods: This randomized clinical trial was performed on patients suffering from severe chronic periodontitis with 22 intrabony defects, the defects were randomly assigned in two equal parallel groups. The periodontal intrabony defects were treated by OFD with amnion chorion membrane (BioXclude{u2122}) as guided tissue regeneration versus demineralized freeze-dried bone allograft putty (C-Blast{u2122}) as bone graft for treatment of intrabony defects. Clinical parameters including plaque index, gingival index, probing pocket depth and clinical attachment level were recorded at baseline, 3 and 6 months post-surgery, while radiographic assessment of bone defect area was recorded at baseline and 6 months postoperatively. Results: The clinical parameters recorded in this trial, in terms of gingival index, probing pocket depth reduction and gain in clinical attachment level, were statistically significant at 3 and 6 months post-surgically compared to baseline measurements. Furthermore, radiographic improvements were observed at 6 months follow up, while no change was recorded for plaque index reported scores. However, no statistically significant difference was detected between the two treatment modalities when compared to each other at different time intervals. Conclusion: Both BioXclude{u2122} and C-Blast{u2122} as regenerative techniques provided promising regenerative potentials in management of periodontal intrabony defects. Moreover, the uneventful healing process associated with their use and predictable results suggest further implementation of them into other studies in the field of periodontal regeneration

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