Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Bone grafting procedures will remain one of the most challenging procedures in dentistry. Many trials using different types of bone grafts and techniques were developed with the hope of getting maximum results. The aim of present study is to evaluate the osseous regenerative capacity of newly developed bone xenograft derived from camel and to compare it versus bovine bone xenograft in experimental maxillary sinus floor augmentation in rabbits. Twelve healthy male White New Zealand rabbits were used in this experiment. Bilateral maxillary sinus floor elevation were prepared and augmented with: deproteinized bovine bone mineral (DBBM) (sites= 12) and deproteinized camelline bone mineral (DCBM) (sites= 12). Group 1 (n=6), rabbits were sacrificed after 4 weeks, and group 2 (n=6) were sacrificed after 8 weeks. Histological and histomorphometric were performed. Mean area percentages of the region of interest were calculated for; new mineralized tissue, residual graft particles and soft tissue. There was no statistically significant difference between DBBM (16.00±5.3)and DCBM (17.3±8.5)after one month in terms of % area of newly formed bone. The % area of newly formed bone at basal zone was higher for DCBM (26.48 ±7.72), at middle zone was higher for DBBM (13.00 ±1.26)and newly formed bone was comparable for 2 groups at the distal zone. Again, there was no statistically significant difference between DBBM (19.9 ±4.9) and DCBM 19.65±8.5)after two months in terms of % area of newly formed bone. The % area of newly formed bone at basal zone was higher for DCBM (29.95±12.9), at middle and distal zones was higher for DBBM. In conclusion, bone regeneration as assessed by area % of newly formed bone did not differ between Bio-Oss® and camelline bone in the basal, middle or distal zones of the augmented sinuses after 4 or 8 weeks in the present study

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