Effects of guanidinoacetic acid supplementation on broiler chickens fed on all-vegetarian diets under normal and challenging conditions / Shady Ahmed Khalil Mohamed Elsaid ; Supervised Ramadan Abdelmontaleb Elbanna , Hossam Ahmed Abdellatif , Ahmed A. Alsagan

Thesis (M.Sc..) - Cairo University - Faculty of Veterinary Medicine - Department of Nutrition

A feeding trial was conducted to investigate the response of broiler chickens to dietary fortification of guanidinoacetic acid (GAA) in a commercial form CreAMINO® and highlighting its impact on growth, serum parameters, total creatine kinase(CK), cardiac creatine kinase (CK- MB) and triiodothyronine (T3)], oxidation stress biomarkers, mitochondrial functions, carcass characteristics, proximate beast muscles composition and the related histomorphological picture as well as histopathological changes of liver tissues at the end of 32 days experimental period under ideal (normal and challenging condition (induced by 1.5 mg/kg dietary fortification of (T3) hormone). A total of 192 one-day old sexed Ross 308 broiler chicks were randomly assigned into 4 equal groups each of 8 replicates (6 chicks/ replicate). The first (G1) served as the control and fed on basal diets without any supplementation, the second (G2) was fed on basal diets supplemented on top with (GAA) that was commercially available CreAMINO® product (600 g/Ton) and the third group (G3) was fed on same diets and fortified with 1.5 ppm triiodothyroinine (T3) as challenging agent. Whereas, the fourth (G4) was fed on the same diets and supplemented with both triiodothyronine and guanidinoacetic acid at the aforementioned levels. Results showed that the overall final body weights and weight gains in GAA supplemented groups were tended to be improved as a result of such supplementation (P=0.05), however feed intake was not significantly affected (P>0.05), but the FCRs were significantly improved (P<0.0001) as compared to non-supplemented. The addition of (T3) hormone resulted in an expected highly significant negative impact on all the examined growth parameters (P<0.0001) as compared to non-challenged groups

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