Remineralizing efficacy of biomimetic self-assembling peptide versus casein phosphopeptide amorphous calcium phosphate and fluoride based delivery systems in artificially induced enamel lesions : An in vitro study / Dina Mohamed Kamal Eldin Mohamed Aly ; Supervised Heba Salah Eldin Hamza , Dina Wafik Elkassas

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Operative Dentistry

Objectives: Investigate the efficacy of biomimetic self-assembling peptide (P11-4) on enamel remineralization compared to casein phosphopeptide amorphous calcium phosphate (CPP-ACPF) and fluoride based delivery systems. Methods: Artificial enamel lesions were created on the buccal surfaces of 40 extracted human molars. Specimens were randomly assigned to 4 groups (n=10) according to the remineralizing agent used: G1-(Control, artificial saliva), G2-(Fluoride varnish), G3- (CPP-ACPF varnish), G4- (Self-assembling peptide agent). All products were applied according to the manufacturer{u2019}s instructions and specimens were stored in a daily renewed artificial saliva for 4 weeks. Surface microhardness (SMH) was assessed at baseline, after demineralization, after 1 week and 4 weeks storage. SMH values were analyzed using ANOVA and Tukey's post-hoc test. Results: Self-assembling peptide showed the highest statistically significant mean SMH followed by fluoride and CPP-ACPF while the lowest mean SMH was found in artificial saliva. However, no statistically significant difference was found between fluoride and CPP-ACPF. Higher statistically significant mean SMH was found after 4 weeks compared to 1 week remineralization in all groups. Conclusions: Self-assembling peptide confers the highest remineralizing efficacy compared to fluoride and CPP-ACPF; showing a promising, non-invasive regeneration potential

Issued also as CD