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Association of obesity with disease severity in rheumatoid arthritis / Nashwa Mohamed Abdellah Mahmoud ; Supervised Siham Aly Mohamed Metawie , Ehab Ibrahim Abouleyon

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nashwa Mohamed Abdellah Mahmoud , 2017Description: 135 P. : charts , facsimiles ; 25cmOther title:
  • العلاقة بين السمنة وشدة المرض في التهاب الروماتويد المفصلي [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Rhumatology and Rehabilitation Summary: Obesity is an extraordinarily common medical condition (Flegal et al., 2010), and competes with smoking as the leading cause of morbidity and mortality among adults in the United States (US) (Jia et al., 2010). Rheumatoid arthritis (RA) is the most frequent chronic autoimmune inflammatory disorder, with a worldwide prevalence around 1%. RA severity is related to joint destruction that is responsible for joint functional disability In rheumatoid arthritis patients (Dénarié et al., 2014). Proliferation of synovial lining cells and infiltration of inflammatory cells, including monocytes and activated leukocytes, into the joint tissues results in formation of pannus tissue that covers the surfaces of articular cartilage and bone and produces pro-inflammatory factors that lead to destruction of cartilage and bone matrix (Karmakar et al., 2010). The serum/synovial fluid ratios of leptin levels were associated with disease duration and erosion .In addition, several in vitro studies sustained the pathogenic role of leptin in RA (Annalisa et al., 2014)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.M.Sc.2017.Na.A (Browse shelf(Opens below)) Not for loan 01010110075215000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.M.Sc.2017.Na.A (Browse shelf(Opens below)) 75215.CD Not for loan 01020110075215000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Rhumatology and Rehabilitation

Obesity is an extraordinarily common medical condition (Flegal et al., 2010), and competes with smoking as the leading cause of morbidity and mortality among adults in the United States (US) (Jia et al., 2010). Rheumatoid arthritis (RA) is the most frequent chronic autoimmune inflammatory disorder, with a worldwide prevalence around 1%. RA severity is related to joint destruction that is responsible for joint functional disability In rheumatoid arthritis patients (Dénarié et al., 2014). Proliferation of synovial lining cells and infiltration of inflammatory cells, including monocytes and activated leukocytes, into the joint tissues results in formation of pannus tissue that covers the surfaces of articular cartilage and bone and produces pro-inflammatory factors that lead to destruction of cartilage and bone matrix (Karmakar et al., 2010). The serum/synovial fluid ratios of leptin levels were associated with disease duration and erosion .In addition, several in vitro studies sustained the pathogenic role of leptin in RA (Annalisa et al., 2014)

Issued also as CD

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